Abstract： Objective： To observe the clinical effect of Shenqi Dihuang Wenshen Decoction on chronic glomerulonephritis of spleen-kidney yang deficiency type and its effect on inflammatory factor levels. Methods：A total of 106 cases of patients with chronic glomerulonephritis of spleen-kidney yang deficiency type admitted to Chinese Medicine Hospital of Puyang from October 2022 to November 2024 were selected and divided into the basic group and the study group according to the random number table method，with 53 cases in each group. The basic group was given conventional treatment including Piperazine Ferulate Tablets，and the study group was additionally treated with Shenqi Dihuang Wenshen Decoction based on the treatment of the basic group. Changes in traditional Chinese medicine syndrome scores， kidney function [24-hour urine protein （24hUpro）， blood urea nitrogen （BUN）， serum creatinine （SCr）， and glomerular filtration rate（GFR）]， and levels of inflammatory factors [tumor necrosis factor- α （TNF- α）， interleukin-6 （IL-6）， interleukin-17 （IL-17）， and C-reactive protein （CRP）] before and after treatment as well as clinical effects and adverse reactions were compared between the two groups. Results： After treatment，the total effective rate was 96.23% （51/53） in the study group and 81.13% （43/53） in the basic group， the difference being significant（ P＜0.05）. After treatment，traditional Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment （P＜0.05），and the score in the study group was lower than that in the basic group （P＜0.05）. The levels of 24hUpro， BUN， and SCr in the two groups were reduced when compared with those before treatment （P＜0.05）， and GFR levels were increased when compared with those before treatment （P＜0.05）； the levels of 24hUpro， BUN， and SCr in the study group were lower than those in the basic group，and the GFR level was higher than that in the basic group （P＜0.05）. Levels of TNF-α，IL-6，IL-17，and CRP in the two groups were decreased when compared with those before treatment （P＜0.05），with lower levels in the study group than in the basic group （P＜0.05）. No significant adverse reactions were observed in either group. Conclusion：Shenqi Dihuang Wenshen Decoction can alleviate symptoms，improve kidney function and inflammation reactions，enhance therapeutic efficacy，and demonstrate high safety in treating chronic glomerulonephritis of spleenkidney yang deficiency type.