基于数据挖掘分析中医药治疗岭南地区咳嗽变异性哮喘用药规律
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R562.25

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深圳市科技计划项目(JCYJ20230807094606014,JCYJ20210324111204013)


Analysis of Medication Patterns in Traditional Chinese Medicine for Cough Variant Asthma in Lingnan Region Based on Data Mining
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    摘要:

    目的:基于数据挖掘分析中医药治疗岭南地区咳嗽变异性哮喘的用药规律。方法:检索中国知 网(CNKI)、中华医学期刊全文数据库、中国生物医学文献服务系统(SinoMed)、维普数据库(VIP) 和万方 数据服务平台(Wanfang) 数据库自2000年1月—2024年6月发表的中医药治疗岭南地区咳嗽变异性哮喘的随 机对照临床研究文献,将符合纳入标准的文献收集整理并建立数据库,运用古今医案云平台对药物进行性味、 归经、使用频数及功效分析、关联规则分析、聚类分析和复杂网络分析。结果:总共筛选出符合纳排标准的文 献共51篇,涉及51个处方,涵盖110味中药,药物累计使用频次568次。药物使用频次前15的药物为甘草、 麻黄、杏仁、法半夏、桔梗、紫菀、蝉蜕、地龙、细辛、紫苏子、陈皮、黄芩、五味子、贝母、茯苓。药性以 温、寒、平3性为主,药味以辛、苦、甘味为主,药物归经多入肺脾,胃、肝、心经次之。药物功效类型排名 前3 为化痰止咳平喘药、解表药、补虚药;关联规则分析可得出11 对组合。聚类分析得出5 个核心类方, 1个核心药物。复杂网络分析得出治疗咳嗽变异性哮喘的最核心中药组合为甘草-麻黄-法半夏-杏仁-紫菀。结 论:中医药治疗岭南地区咳嗽变异性哮喘以宣肺解表祛风、化痰止咳平喘为核心治法,同时结合岭南地区患者 体质特点,常用健脾补虚、化痰燥湿、清热、理气、养阴之品,善于运用岭南道地药材,为该地区运用中医药 治疗咳嗽变异性哮喘提供临床用药借鉴。

    Abstract:

    Abstract: Objective: To analyze the medication patterns of traditional Chinese medicine in treating cough variant asthma in the Lingnan region through data mining. Methods: Clinical research literature on randomized controlled trials of traditional Chinese medicine for cough variant asthma in Lingnan region published between January 2000 and June 2024 was retrieved from CNKI, Chinese Medical Association Journal Database, SinoMed, VIP and Wanfang databases. Literature meeting inclusion criteria was collected to establish a database. The Ancient and Modern Medical Case Cloud Platform was used to analyze herb properties, flavors, channel tropisms, frequency of use, efficacy,association rules analysis,cluster analysis,and complex network analysis. Results : A total of 51 articles meeting the criteria were screened , involving 51 prescriptions,110 herbs,and a cumulative frequency of 568 herb uses. The top 15 most frequently used herbs were: Glycyrrhizae Radix et Rhizoma, Ephedrae Herba, Armeniacae Semen Amarum, Pinelliae Rhizoma Praeparatum, Platycodonis Radix, Asteris Radix et Rhizoma, Cicadae Periostracum, Pheretima, Asari Radix et Rhizoma, Perillae Fructus, Citri Reticulatae Pericarpium, Scutellariae Radix,Schisandrae Chinensis Fructus,Fritillaria,and Poria. Herb properties were mainly warm,cold,and neutral; flavors were predominantly pungent, bitter, and sweet. Herbs primarily entered the lung and spleen channels, followed by the stomach,liver,and heart channels. The top three efficacy categories were:phlegm-resolving,cougheasing, and asthma-relieving herbs, exterior-releasing herbs, and deficiency-tonifying herbs. Association rule analysis yielded 11 herb pairs. Cluster analysis identified five core formula clusters and one core herb. Complex network analysis indicated the core combination for cough variant asthma treatment:Glycyrrhizae Radix et Rhizoma,Ephedrae Herba, Pinelliae Rhizoma Praeparatum, Armeniacae Semen Amarum, and Asteris Radix et Rhizoma. Conclusion: Traditional Chinese medicine treatment for cough variant asthma in Lingnan region focuses on diffusing the lung and releasing the exterior,dispelling wind,resolving phlegm,easing cough,and relieving asthma. It also considers the constitutional characteristics of Lingnan patients, frequently incorporating herbs to strengthen the spleen, tonify deficiency, resolve phlegm, dry dampness, clear heat, regulate qi, and nourish yin, with adept use of Lingnanspecific medicinal materials, providing clinical guidance for traditional Chinese medicine treatment of cough variant asthma in this region.

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陈奕微,张婷,刘玉.基于数据挖掘分析中医药治疗岭南地区咳嗽变异性哮喘用药规律[J].新中医,2026,58(1):1-7

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  • 在线发布日期: 2026-01-12
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