Abstract：Objective：To observe the effect of Huazhuo Tongmai Prescription in the treatment of coronary heart disease （CHD） of phlegm-stasis obstruction type. Methods： A total of 120 patients with CHD of phlegm-stasis obstruction type admitted to the Department of Cardiology， Haining Hospital of Chinese Medicine from September 2021 to August 2023 were selected. They were divided into the observation group and the control group by the random number table method，with 60 cases in each group. The control group was given conventional modern medical treatment， while the observation group was given Huazhuo Tongmai Prescription on the basis of the control group's treatment. The incidence of adverse reactions was observed. The changes in traditional Chinese medicine （TCM） syndrome scores， blood lipids （serum total cholesterol， high-density lipoprotein cholesterol， low-density lipoprotein cholesterol， triglycerides）， and blood glucose （fasting blood glucose， 2-hour postprandial blood glucose， glycated hemoglobin） before and after treatment were compared between the two groups. Results：After treatment，the TCM syndrome scores in the observation group were decreased when compared with those before treatment and were lower than those in the control group，differences being significant （P＜0.05）；there was no statistically significant difference in the control group before and after treatment or between the two groups （P＞0.05）. After treatment，the serum total cholesterol and low-density lipoprotein cholesterol in the observation group were decreased when compared with those before treatment and were lower than those in the control group， differences being significant （P＜0.05）； there was no significant difference in triglycerides and high-density lipoprotein cholesterol between the two groups before and after treatment or between the two groups （P＞0.05） . After treatment，the fasting blood glucose and 2-hour postprandial blood glucose in the observation group were decreased when compared with those before treatment （P＜0.05），and the fasting blood glucose was lower than that in the control group （P＜0.05） . There was no significant difference in glycated hemoglobin level between the two groups before and after treatment or between the two groups （P＞0.05）. During the treatment，one patient in the observation group had diarrhea，and the symptoms disappeared after treatment. Conclusion：Huazhuo Tongmai Prescription has a good effect in the treatment of CHD of phlegm-stasis obstruction type， and is helpful for controlling blood lipids and blood glucose.