Abstract：Objective：To observe the curative effect of fumigation-wash of Qingre Liangxue Jiedu Prescription for postoperative management of mixed hemorrhoids. Methods： A total of 100 patients who underwent surgery of mixed hemorrhoids in the Anji Third People's Hospital from January 2020 to December 2024 were selected and divided into the control group and the Chinese medicine group according to the random number table method， with 50 cases in each group. The control group received conventional dressing change and potassium permanganate hip bath，and the Chinese medicine group was given conventional dressing change and fumigation-wash and hip bath with Qingre Liangxue Jiedu Prescription for 14 days. The clinical effects， incidence of adverse reactions， the postoperative recovery， and the changes in wound morphology， scores of Visual Analogue Scale （VAS） for pain and levels of inflammatory indexes [interleukin-8 （IL-8），interleukin-4 （IL-4），interleukin-17 （IL-17），tumor necrosis factor-α （TNF-α）] before and after treatment were compared between the two groups. Results： After treatment， the total effective rate was 96.00% （48/50） in the Chinese medicine group and 82.00% （41/50） in the control group， the difference being significant （P＜0.05）. The hospitalization time，wound healing time and wound bleeding time in the Chinese medicine group were shorter than those in the control group，differences were statistically significant （P＜0.05）. After treatment， the VAS scores，wound swelling scores，and wound drainage scores in the two groups were decreased when compared with those before treatment （P＜0.05），and the above three scores in the Chinese medicine group were lower than those in the control group （P＜0.05）. After 7 days of treatment， the numbers of new capillaries and fibroblasts in the two groups were increased when compared with those before treatment （P＜0.05）， and the above two numbers in the Chinese medicine group were higher than those in the control group （P＜0.05）； after 14 days of treatment， the numbers of new capillaries and fibroblasts in the two groups were elevated when compared with those before treatment （P＜0.05）； the above two numbers in the Chinese medicine group were lower than those after 7 days of treatment （P＜0.05），and the above two numbers in the Chinese medicine group were lower than those in the control group （P＜0.05）. After treatment， the levels of IL-8， IL-17， and TNF-α in the two groups were reduced when compared with those before treatment （P＜0.05），and the IL-4 levels were elevated when compared with those before treatment （P＜0.05）；the levels of IL-8，IL-17，and TNF-α in the Chinese medicine group were lower than those in the control group （P＜0.05）， and the IL-4 level was higher than that in the control group （P＜0.05）. During the treatment， there was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups （P＞0.05）. Conclusion： Fumigation-wash of Qingre Liangxue Jiedu Prescription has a good effect for postoperative management of mixed hemorrhoids，which can relieve pain，accelerate wound healing，reduce inflammation responses，improve clinical symptoms，and promote rehabilitation.