Abstract：Objective：To observe the curative effect of Huaier Granules in the treatment of non-small cell lung cancer after surgery. Methods： A total of 98 patients with non-small cell lung cancer admitted to Deqing County People's Hospital from October 2021 to October 2024 were selected and divided into the control group （50 cases） and the combination group （48 cases） according to different treatment plans. The control group was treated with videoassisted thoracoscopic surgery （VATS） anatomic resection for lung cancer，and the combination group was additionally treated with Huaier Granules based on the treatment in the control group. With 21 days as a cycle，continuous treatment for 3 cycles was given. The clinical efficacy，and the changes in traditional Chinese medicine syndrome scores，quality of life scores [Functional Assessment of Cancer Therapy-Lung （FACT-L）]， levels of immune indexes[T lymphocytes （CD4+ ， CD8+ ， CD4+/CD8+）， natural killer （NK） cells]， levels of inflammatory markers [NOD-like receptor thermal protein domain associated protein 3 （NLRP3），interleukin-4 （IL-4），apoptosis-associated specklike protein containing a CARD （ASC）]，tumor markers [carcinoembryonic antigen （CEA），squamous cell carcinoma antigen（ SCC-Ag），neuron-specific enolase（ NSE）] before and after treatment were respectively compared between the two groups. Results： After treatment， the total effective remission rate and total effective control rate in the combination group were higher than those in the control group，differences being significant（ P＜0.05）. After treatment， the traditional Chinese medicine syndrome scores of shortness of breath，spiritless fatigue and blood-steaked phlegm in the two groups were decreased when compared with those before treatment （P＜0.05）， and the FACT-L scores were increased when compared with those before treatment （P＜0.05）； the above three traditional Chinese medicine syndrome scores in the combination group were lower than those in the control group （P＜0.05），and the FACT-L score was higher than that in the control group （P＜0.05）. After treatment，the levels of CD4+，NK，and CD4+/CD8+ in the two groups were up-regulated when compared with those before treatment，and there was significance being found in the comparison before and after treatment in the combination group （P＜0.05）；the levels of CD4+，NK，and CD4+/CD8+ in the combination group were higher than those in the control group （P＜0.05）. After treatment，the levels of NLRP3， IL-4，and ASC in the two groups were elevated when compared with those before treatment （P＜0.05），and the levels of the above three indexes in the combination group were lower than those in the control group （P＜0.05）. After treatment， the levels of CEA， SCC-Ag， and NSE in the two groups were reduced when compared with those before treatment （P＜0.05），and the above levels of the three indexes in the combination group were lower than those in the control group （P＜0.05）. There was no statistically significant difference in the incidence of adverse reactions between the two groups （P＞0.05）. Conclusion：Huaier Granules have a definite curative effect on non-small cell lung cancer after surgery， which can improve the immunity of patients， reduce the inflammatory responses， and improve the quality of life.