补阳还五汤联合西药治疗老年中风后遗症临床疗效及安全性Meta 分析
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R255.2

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广东省中医药局科研项目(20251143)


Meta-Analysis of Clinical Efficacy and Safety of Buyang Huanwu Tang Combined with Western Medicine in Treating Post-Stroke Sequelae in the Elderly
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    摘要:

    目的:系统评价补阳还五汤联合西药治疗老年中风后遗症的临床疗效及安全性。方法:计算机检 索2004年1月—2025年1月中国知网(CNKI)、万方、PubMed等中英文数据库,纳入补阳还五汤联合西药对 比单纯西药治疗老年中风后遗症的随机对照试验(RCT)。由2名研究者独立筛选文献、提取数据并评估偏倚 风险。采用RevMan 5.3软件进行Meta分析,效应量以比值比(OR) 或均数差(MD) 及95%置信区间(CI) 表 示。结果: 共纳入9 项RCT, 762 例患者。Meta 分析显示, 试验组总有效率高于对照组[OR=0.18, 95%CI (0.11, 0.29), P<0.000 01]; 试验组神经功能缺损评分改善更显著[MD=-4.69, 95%CI (-5.13, -4.25), P<0.000 01];试验组全血黏度[MD=-0.97,95%CI(-1.17,-0.77),P<0.000 01]、血浆黏度[MD= -1.81,95%CI(-1.99,-1.62),P<0.000 01]及纤维蛋白原[MD=-0.71,95%CI(-0.85,-0.58),P<0.000 01] 均优于对照组;2组不良反应发生率比较,差异无统计学意义[OR=0.53,95%CI(0.17,1.64),P=0.27]。结 论:补阳还五汤联合西药可显著改善老年中风后遗症患者的神经功能及血液流变学指标,且安全性良好。

    Abstract:

    Abstract: Objective: To systematically evaluate the clinical efficacy and safety of Buyang Huanwu Tang combined with conventional western medicine in the treatment of post-stroke sequelae in the elderly. Methods: A computer-based search was conducted in Chinese and English databases,including CNKI,Wanfang,PubMed,etc., from January 2004 to January 2025, to identify randomized controlled trials (RCTs) comparing the combination of Buyang Huanwu Tang and western medicine with western medicine alone in the treatment of post-stroke sequelae in the elderly. Two researchers independently screened the literature, extracted data, and assessed the risk of bias. Metaanalysis was performed using RevMan 5.3 software, with effect sizes expressed as odds ratios (OR) or mean differences( MD) and 95% confidence intervals( CI). Results:A total of 9 RCTs involving 762 patients were included. The Meta-analysis showed that the total effective rate was higher in the trial group than in the control group [OR= 0.18, 95%CI(0.11, 0.29), P<0.000 01];the improvement in neurological deficit scores was more significant in the trial group [MD=-4.69, 95%CI (-5.13, -4.25), P<0.000 01]; the trial group had better outcomes in whole blood viscosity [MD=-0.97,95%CI (-1.17,-0.77),P<0.000 01],plasma viscosity [MD=-1.81,95%CI (-1.99, -1.62), P<0.000 01], and fibrinogen [MD=-0.71, 95%CI (-0.85, -0.58), P<0.000 01] compared with the control group; there was no statistically significant difference in the incidence of adverse reactions between the two groups [OR=0.53, 95%CI (0.17, 1.64), P=0.27]. Conclusion: Buyang Huanwu Tang combined with western medicine can significantly improve the neurological function and hemorheological indicators of patients with post-stroke sequelae in the elderly,and has good safety.

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周慧萍,温丹婷.补阳还五汤联合西药治疗老年中风后遗症临床疗效及安全性Meta 分析[J].新中医,2026,58(1):143-148

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  • 在线发布日期: 2026-01-12
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