Abstract：Objective：To observe the efficacy and safety of Zhimu Huoteng Decoction combined with biomimetic electrical stimulation and western medicine in the treatment of infertility due to diminished ovarian reserve （DOR） with kidney deficiency and blood stasis syndrome. Methods：A total of 110 patients with infertility due to DOR with kidney deficiency and blood stasis syndrome admitted to The General Hospital of Jinshui District，Zhengzhou City，from June 2021 to June 2023 were selected and randomly divided into the electrostimulation group and the comprehensive group. Both groups received oral Estradiol Valerate Tablets/Estradiol Cyproterone Acetate Tablets and biomimetic electrical stimulation therapy， while the comprehensive group additionally received Zhimu Huoteng Decoction. Both groups underwent treatment for at least three consecutive menstrual cycles. Before treatment and after three menstrual cycles of treatment， the following were measured in both groups： the proportion of Th1 and Th2 cells and the Th1/Th2 ratio； sex hormone indicators [follicle-stimulating hormone （FSH），luteinizing hormone （LH），FSH/LH ratio，anti- Müllerian hormone （AMH），estradiol（E2）]；antral follicle count （AFC）；ovarian volume （OV）；and ovarian stromal artery blood flow parameters [peak systolic velocity （PSV），end-diastolic velocity （EDV），vascularization index（VI）， flow index（FI）]. Traditional Chinese medicine syndrome scores and Pictorial Blood Loss Assessment Chart （PBAC） scores were assessed. Clinical efficacy，pregnancy rate，miscarriage rate，and incidence of adverse reactions were also calculated. Results： After treatment， the total effective rate in the comprehensive group was higher than that in the electrostimulation group （P＜0.05）. In both groups，the Th1 cell proportion and Th1/Th2 ratio decreased compared to before treatment， while the Th2 cell proportion increased compared to before treatment， with all differences being statistically significant （P＜0.05）. The Th1 cell proportion and Th1/Th2 ratio in the comprehensive group were lower than those in the electrostimulation group， and the Th2 cell proportion was higher than that in the electrostimulation group， with all differences being statistically significant （P＜0.05）. FSH levels， LH levels， and FSH/LH ratios decreased in both groups compared to before treatment， while AMH and E2 levels increased compared to before treatment，with all differences being statistically significant （P＜0.05）. FSH level，LH level and FSH/LH ratio in the comprehensive group were lower than those in the electrostimulation group，while the AMH and E2 levels were higher than those in the electrostimulation group，with all differences being statistically significant （P＜0.05）. AFC and OV increased in both groups compared to before treatment （P＜0.05）. AFC was higher and OV was larger in the comprehensive group compared to the electrostimulation group （P＜0.05）. PSV，EDV，VI，and FI values increased in both groups compared to before treatment （P＜0.05）. PSV， EDV， VI， and FI values were higher in the comprehensive group than in the electrostimulation group （P＜0.05）. Traditional Chinese medicine syndrome scores decreased and PBAC scores increased in both groups compared to before treatment （P＜0.05）. Traditional Chinese medicine syndrome scores were lower and PBAC scores were higher in the comprehensive group compared to the electrostimulation group （P＜0.05）. The pregnancy rate in the comprehensive group was higher than that in the electrostimulation group， and the miscarriage rate in the comprehensive group was lower than that in the electrostimulation group， but the difference was not statistically significant （P＞0.05）. There was no statistically significant difference in the incidence of adverse reactions between the two groups （P＞0.05）. Conclusion： The application of Zhimu Huoteng Decoction combined with biomimetic electrical stimulation and western medicine in patients with infertility due to DOR with kidney deficiency and blood stasis syndrome can improve clinical efficacy， effectively enhance ovarian function，maintain stable sex hormone levels，and demonstrates good safety.