Abstract： Objective： To observe the clinical effect of thumbtack needle combined with point application for chronic obstructive pulmonary disease （COPD） and its effect on dyspnea indexes and lung function. Methods：A total of 100 COPD patients admitted to Huzhou Hospital of Chinese Medicine Affiliated to Zhejiang Chinese Medical University from April 2020 to April 2022 were selected and randomly divided into the control group and the treatment group using the random number table method，with 50 cases in each group. The control group was treated with routine western medicine such as Salmeterol Xinafoate and Fluticasone Propionate Powder for Inhalation and Salbutamol Sulfate for Inhalation，and the treatment group was additionally treated with thumbtack needle combined with point application based on the treatment of the control group. The scores of modified Medical Research Council （mMRC），the forced vital capacity （FVC）， the ratio of forced expiratory volume in the first second to forced vital capacity （FEV1/FVC）， the levels of D-dimer （D-D），thrombin-antithrombin complex （TAT），and fibrinogen （Fib） before and after treatment as well as the clinical effects were compared between the two groups. Results：The total effective rate was 94.00%（47/50） in the treatment group and 72.00% （36/50） in the control group， the difference being significant （P＜0.05）. After treatment，the mMRC scores in the two groups were decreased when compared with those before treatment （P＜0.05）， and the mMRC score in the treatment group was lower than that in the control group （P＜0.05）. After treatment，the levels of FVC and FEV1/FVC in the two groups were increased when compared with those before treatment （P＜0.05）， and the levels of FVC and FEV1/FVC in the treatment group were higher than those in the control group （P＜0.05）. After treatment， the levels of D-D， TAT， and Fib in the two groups were decrease when compared with those before treatment（ P＜0.05），and the levels of D-D，TAT，and Fib in the treatment group were lower than those in the control group （P＜0.05）. Conclusion：Based on routine western medicine treatment，the additional application of thumbtack needle combined with point application has a definite curative effect in the treatment of COPD，which can regulate blood hypercoagulable state，as well as improve lung function and dyspnea.