Abstract： Objective： To observe the clinical effect of Huayu Xiaotong Decoction combined with collateral puncture and bloodletting therapy in the treatment of lumbar disc herniation （LDH）. Methods：A retrospective analysis was conducted on the clinical data of 98 LDH patients admitted to Zhenhai Hospital of Traditional Chinese Medicine from January 2021 to September 2024. They were divided into the control group and the study group according to different treatment methods，with 49 cases in each group. The control group received conventional traction training and symptomatic treatment with analgesic medications，while the study group was additionally treated with Huayu Xiaotong Decoction combined with collateral puncture and bloodletting therapy. Both groups were treated for four weeks. The clinical effects in the two groups were evaluated， and the Oswestry Disability Index （ODI） scores， Visual Analogue Scale （VAS） scores，serum pain mediator [prostaglandin E2 （PGE2），bradykinin （BK），5-hydroxytryptamine （5- HT）] levels and hemorheological indicators [fibrinogen （FIB）， whole blood high shear viscosity （WBHSV）， whole blood low shear viscosity （WBLSV），plasma viscosity （PV）] were compared between the two groups before and after treatment. Results： The total effective rate in the study group was 93.88% （46/49）， which was higher than 77.55% （38/49） in the control group （P＜0.05）. After treatment， the ODI and VAS scores of both groups were decreased when compared with those before treatment （P＜0.05），and the ODI and VAS scores in the study group were lower than those in the control group （P＜0.05）. After treatment，the levels of PGE2，BK，and 5-HT in both groups were decreased when compared with those before treatment （P＜0.05），and the levels of PGE2，BK，and 5-HT in the study group were lower than those in the control group （P＜0.05）. After treatment， the levels of FIB， WBHSV， WBLSV，and PV in both groups were decreased when compared with those before treatment （P＜0.05），and the levels of FIB， WBHSV， WBLSV， and PV in the study group were lower than those in the control group （P＜0.05）. Conclusion： Huayu Xiaotong Decoction combined with collateral puncture and bloodletting therapy has a significant effect in the treatment of LDH，which can effectively reduce patients′ pain，alleviate lumbar dysfunction，and promote the recovery of hemodynamics.