脐针疗法、中药调周法联合盆底仿生物电刺激治疗薄型子宫内膜不孕症临床研究
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R271.14

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2022年浙江中医药大学校级科研项目(2022FSYYZY19)


Clinical Study on Umbilical Acupuncture, Menstrual Cycle Regulation with Chinese Medicine,and Pelvic Floor Biomimetic Electrical Stimulation in the Treatment of Thin Endometrial Infertility
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    摘要:

    目的:观察脐针疗法、中药调周法联合盆底仿生物电刺激治疗肾虚肝郁型薄型子宫内膜不孕症的 临床疗效。方法:纳入2023年1月—2024年11月嘉兴市中医医院治疗的120例肾虚肝郁型薄型子宫内膜不孕 症患者作为研究对象,随机分为对照组和观察组各60例。对照组予雌二醇片/雌二醇地屈孕酮片治疗,观察组 予脐针疗法、中药调周法联合盆底仿生物电刺激治疗,2组均治疗3个月经周期。治疗前后评估中医证候评分, 检测血清生殖激素[雌激素(E2)、孕酮(P)、促卵泡刺激素(FSH)] 含量、子宫内膜厚度和子宫动脉血流 参数[搏动指数(PI)、阻力指数(RI)]。比较2组的临床疗效。治疗结束后随访6个月,统计2组的妊娠成 功率。结果:治疗3个月经周期后,观察组总有效率(91.67%,55/60) 高于对照组(73.33%,44/60)(P< 0.05)。2组中医证候积分均较治疗前下降(P<0.05);观察组中医证候积分低于对照组(P<0.05)。2组血清 E2、P水平均较治疗前升高,FSH水平均较治疗前下降,差异均有统计学意义(P<0.05);观察组血清E2、P水 平均高于对照组,FSH水平低于对照组,差异均有统计学意义(P<0.05)。2组子宫内膜厚度值均较治疗前增 加(P<0.05);观察组子宫内膜厚度值大于对照组(P<0.05)。2组子宫动脉PI、RI值均较治疗前降低(P< 0.05); 观察组子宫动脉PI、RI值均低于对照组(P<0.05)。观察组妊娠成功率(61.67%,37/60) 高于对照 组(31.67%,19/60)(P<0.05)。结论:应用脐针疗法、中药调周法与盆底仿生物电刺激相结合的综合疗法治 疗肾虚肝郁型薄型子宫内膜不孕症,可通过调节激素分泌水平,促进子宫血液循环的机制,有效缓解肾虚肝郁 证相关证候,增加子宫内膜厚度,提高妊娠率。

    Abstract:

    Abstract: Objective: To observe the clinical efficacy of combining umbilical acupuncture, menstrual cycle regulation with Chinese medicine,and pelvic floor biomimetic electrical stimulation in the treatment of thin endometrial infertility of kidney deficiency and liver stagnation type. Methods: A total of 120 patients with thin endometrial infertility of kidney deficiency and liver stagnation type admitted to Jiaxing Hospital of Traditional Chinese Medicine from January 2023 to November 2024 were enrolled and randomly divided into the control group and the observation group,with 60 cases in each group. The control group received Estradiol Tablets/Estradiol and Dydrogesterone Tablets, while the observation group received a combined therapy of umbilical acupuncture, menstrual cycle regulation with Chinese medicine, and pelvic floor biomimetic electrical stimulation. Both groups were treated for three menstrual cycles. Before and after treatment, traditional Chinese medicine syndrome scores were assessed,serum reproductive hormone levels [estradiol (E2),progesterone (P),follicle-stimulating hormone (FSH)],endometrial thickness, and uterine artery blood flow parameters [pulsatility index (PI), resistance index (RI) ] were measured. The clinical efficacy of the two groups was compared. A six-month follow-up was conducted after treatment to compare the pregnancy success rates between the two groups. Results:After three menstrual cycles of treatment,the total effective rate in the observation group was 91.67% (55/60), significantly higher than that of 73.33% (44/60) in the control group (P< 0.05). Traditional Chinese medicine syndrome scores decreased in both groups compared with those before treatment (P<0.05),with the observation group showing lower scores than the control group (P<0.05). Serum E2 and P levels increased,while FSH levels decreased in both groups compared with those before treatment,with statistically significant differences (P<0.05);and the observation group had higher serum E2 and P levels and lower FSH levels than the control group (P<0.05). Endometrial thickness increased in both groups compared with that before treatment (P<0.05),with the observation group showing greater thickness than the control group (P<0.05). Uterine artery PI and RI values decreased in both groups compared with those before treatment (P<0.05),with the observation group exhibiting lower values than the control group (P<0.05). The pregnancy success rate in the observation group was 61.67% (37/60),significantly higher than that of 31.67% (19/60) in the control group (P<0.05). Conclusion:The comprehensive therapy combining umbilical acupuncture, menstrual cycle regulation with Chinese medicine, and pelvic floor biomimetic electrical stimulation in the treatment of thin endometrial infertility of kidney deficiency and liver stagnation type can effectively improve traditional Chinese medicine syndromes,increase endometrial thickness,and improve pregnancy rates. The mechanism may involve regulating hormone secretion levels and promoting uterine blood circulation.

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王华,刘芳,姚娅丹.脐针疗法、中药调周法联合盆底仿生物电刺激治疗薄型子宫内膜不孕症临床研究[J].新中医,2026,58(3):127-133

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  • 在线发布日期: 2026-02-08
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