Abstract： Objective： To analyze the potential mechanism of the Wenzhong Huazhuo Prescription in treating chronic atrophic gastritis （CAG） based on network pharmacology and molecular docking technology. Methods： Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform （TCMSP） was used to screen for the targets of the ingredients in Wenzhong Huazhuo Prescription. The GeneCards，DrugBank，DisGeNET and OMIM databases were integrated to predict and screen for CAG-related targets， and the active ingredients for CAG in the prescription. Protein-protein interaction networks were constructed by integrating the resources in STRING database and visualized with Cytoscape to identify the core targets in networks. A "herbs-active ingredient-target" network was established to screen for core active ingredients. Gene Ontology （GO） analysis and Kyoto Encyclopedia of Genes and Genomes （KEGG） pathway enrichment analysis of the targets in the prescription were performed using the Metascape database. Molecular docking of core ingredients with their targets was validated. Results ： A total of 134 potential active ingredients were screened， involving 274 targets. Among these， 85 active ingredients were related to disease targets. The core ingredients of Wenzhong Huazhuo Prescription were identified as quercetin， kaempferol， luteolin， β-sitosterol， hederagenin， naringenin and nobiletin. Key targets included AKT serine/threonine-protein kinase 1 （AKT1），tumor necrosis factor （TNF），transcription factor AP-1 subunit （JUN），interleukin-6 （IL-6），tumor protein p53 （TP53）， interleukin-1β （IL-1β）， prostaglandin-endoperoxide synthase 2 （PTGS2）， and epidermal growth factor receptor （EGFR）. GO enrichment returned 1 838 biological processes， 88 cellular components and 143 molecular functions. KEGG analysis revealed significant involvement of the cancer，AGE-RAGE，TNF，PI3KAKT， IL-17，apoptosis，and MAPK signaling pathways. The binding energies between the main active ingredients and the core targets were all less than O kcal/mol. Conclusion：Wenzhong Huazhuo Prescription exerts therapeutic effects against CAG mainly through quercetin， kaempferol， luteolin， β-sitosterol， hederagenin， and naringenin， and nobiletion acting on AKT1，TNF，JUN，TP53，IL-6，IL-1β，EGFR，and PTGS2 thereby modulating PI3K-AKT， TNF-α，IL-17，cancer，lipid-metabolism/atherosclerosis，proteoglycan-metabolism，and AGE-RAGE pathways to suppress inflammation，protect the gastric mucosa，and inhibit carcinogenesis.