Abstract：Chemotherapy-induced myelosuppression in breast cancer is a key factor limiting clinical efficacy. As a traditional therapy，moxibustion demonstrates a unique "theoretical principle-method-prescription-acupoint selection" framework in treating post-chemotherapy myelosuppression，showing clinical potential in ameliorating this condition. It effectively improves peripheral blood parameters， shortens the suppression period， and exhibits a favorable safety profile. Its mechanisms involve repairing bone marrow structure， promoting hematopoietic stem cell proliferation， improving the hematopoietic microenvironment，reducing DNA damage，and achieving multi-target protective effects through regulation of key pathways such as Wnt/β-catenin and Notch. Future studies should validate its efficacy via multicenter large-sample trials and further elucidate its mechanisms using molecular biology techniques to provide a scientific basis for clinical application.