Abstract： Objective： To observe the clinical efficacy of governor vessel-dredging and mind-regulating acupuncture as an adjuvant therapy for neurological dysfunction in patients after interventional surgery for acute large vessel occlusion ischemic stroke （AIS-LVO）. Methods： A retrospective analysis was conducted on 116 AIS-LVO patients who underwent interventional surgery at Dongguan Hospital of Guangzhou University of Chinese Medicine from November 2022 to December 2024. Patients were divided into an observation group （60 cases） and a control group （56 cases） based on whether they received acupuncture within 28 days postoperatively. After matching for relevant factors ， 39 matched pairs （39 cases per group） were successfully established. The control group received conventional treatment， while the observation group received governor vessel-dredging and mind-regulating acupuncture combined with conventional treatment. Both groups were treated for 4 weeks. Clinical efficacy， disability rate， recurrence rate， National Institutes of Health Stroke Scale （NIHSS） scores， Fugl-Meyer Assessment （FMA） scores，Modified Barthel Index （MBI） scores，and Kubota Drinking Water Test （KDWT） scores were assessed before treatment and at 4 weeks after treatment，and at 12 and 24 weeks postoperatively. Results：At 4 weeks after treatment， the total effective rate was 89.7% （35/39） in the observation group and 76.9% （30/39） in the control group， with a significant difference between the two groups （P＜0.05）. At 4 weeks after treatment， and at 12 and 24 weeks postoperatively，NIHSS，FMA，MBI，and KDWT scores in both groups were better than those before treatment （P＜ 0.05），and the scores of the observation group were better than those in the control group at the same time points （P＜ 0.05）. At 12 weeks postoperatively， there was no significant difference in disability rates between the two groups （P ＞ 0.05）. At 24 weeks postoperatively， the disability rate in the observation group was 20.5% （8/39）， lower than that of 33.3% （13/39） in the control group，with a significant difference between the two group （P＜0.05）. At 24 weeks postoperatively，the recurrence rate of cerebral infarction was 17.1% （6/35） in the observation group and 36.7% （11/30） in the control group， with a significant difference between the two groups （P＜0.05）. Conclusion： Governor vessel-dredging and mind-regulating acupuncture as an adjuvant therapy for AIS-LVO patients after interventional surgery is superior to conventional treatment alone in improving motor and swallowing functions，reducing disability rates，and lowering recurrence risk.