Abstract：Objective：To observe the clinical efficacy of acupuncture combined with Cangfu Daotan Decoction in the treatment of polycystic ovary syndrome （PCOS） complicated by insulin resistance （IR） of phlegm-dampness type， and its effects on inflammation and oxidative stress in patients. Methods： A total of 100 patients with PCOS complicated by IR of phlegm-dampness type treated at the Second Outpatient Department of Henan Provincial Government Agencies from April 2023 to April 2024 were selected and divided into the control group and the treatment group using the random number table method，with 50 cases in each group. During the study，one case excluded from the control group and two from the treatment group. Both groups received conventional western medical treatment. The control group additionally received Cangfu Daotan Decoction，while the treatment group received acupuncture combined with Cangfu Daotan Decoction. After three consecutive menstrual cycles of treatment，the clinical efficacy was compared between the two groups. Changes in sex hormones [anti-Müllerian hormone （AMH）， luteinizing hormone （LH）， androstenedione （AN）， follicle-stimulating hormone （FSH）]， inflammatory indicators [monocyte chemoattractant protein-1 （MCP-1）， heat shock protein 70 （HSP70）]， oxidative stress indicators [reactive oxygen species （ROS）， superoxide dismutase （SOD）]，ovarian hemodynamics （peak systolic velocity and resistance index of ovarian artery）， ovarian morphology indicators （ovarian volume and capsule thickness）， fasting blood glucose， fasting insulin， adiponectin， and homeostasis model assessment of insulin resistance （HOMA-IR） were observed before and after treatment. Results： The total effective rate in the treatment group was 95.83% （46/48）， which was higher than 81.63%（ 40/49） in the control group（ P＜0.05）. After treatment，levels of AMH，LH，AN，FSH，MCP-1，HSP70， ROS，fasting blood glucose，fasting insulin，and HOMA-IR decreased，while SOD and adiponectin levels increased in both groups compared to before treatment；peak systolic velocity of the ovarian artery increased，while the ovarian artery resistance index，ovarian volume，and ovarian capsule thickness decreased compared to before treatment （P＜ 0.05）. The treatment group showed lower levels of AMH， LH， AN， FSH， MCP-1， HSP70， ROS， fasting blood glucose， fasting insulin， and HOMA-IR， higher SOD and adiponectin levels， higher peak systolic velocity of the ovarian artery，lower ovarian artery resistance index，smaller ovarian volume，and thinner ovarian capsule thickness compared to the control group （P＜0.05）. Conclusion： Acupuncture combined with Cangfu Daotan Decoction in the treatment of PCOS complicated by IR of phlegm-dampness type can regulate sex hormone levels，reduce inflammation and oxidative stress damage， improve IR， ovarian hemodynamics， and ovarian morphology， thereby enhancing therapeutic efficacy.