Abstract：Objective：To analysis the patterns of acupuncture and moxibustion in the treatment of pruritus using data mining technology. Methods：Clinical literature on acupuncture and moxibustion for pruritus published from the inception of the databases until March 20， 2025， was retrieved from the China National Knowledge Infrastructure（ CNKI），China Science and Technology Journal Database（ VIP），and Wanfang Data Knowledge Service Platform （Wanfang）. Literature meeting the inclusion criteria was extracted and subsequently analyzed for general information， acupoint application frequency， acupoint location distribution， specific acupoint statistics， cluster analysis， and association rule analysis. Results： A total of 57 articles were included， involving 46 acupoints from 12 meridians， with a total acupoint application frequency of 278. Eight acupuncture and moxibustion therapies were involved， with the top three being conventional acupuncture， fire needling， and electroacupuncture. The top three meridians by usage frequency were the foot-Taiyin spleen meridian，the hand-Yangming large intestine meridian，and the foot-Taiyang bladder meridian. The top three acupoints by application frequency were Xuehai（SP10）， Quchi （LI11）， and Zusanli （ST36）. The employed acupoints were primarily distributed in the lower limbs， upper limbs， and the back/lumbar/sacral region. The top three specific acupoint by application frequency were sea points， primary points， and lower sea points. Cluster analysis identified key acupoint combinations： Quchi （LI11）- Xuehai（ SP10）-Hegu（ LI4）-Sanyinjiao（ SP6）-Zusanli（ ST36）-Chize（ LU5）-Geshu（ BL17）-Baichongwo（ EX-LE3）. Association analysis revealed strongly associated acupoint combinations：Xuehai（ SP10）-Quchi（ LI11），Quchi（ LI11）- Zusanli（ ST36），and Xuehai（ SP10）-Zusanli（ ST36）. Conclusion：Acupuncture and moxibustion in the treatment of pruritus is primarily based on the important etiology and pathogenesis of "wind，" emphasizing treatment principles from the perspective of "wind" and "blood." It frequently targets meridians rich in qi and blood，such as the spleen，large intestine， and bladder meridians， to achieve the effect of harmonizing blood and dispelling wind. The application of specific acupoints like sea points， primary points， lower sea points， and back-Shu points is emphasized to achieve simultaneous treatment of diseases of meridians and zang-fu organs. Clinical practice focuses on syndrome differentiation for acupoint modification and the flexible use of therapies such as conventional acupuncture， fire needling， electroacupuncture，and acupoint injection to achieve therapeutic goals.