Abstract：Dengue fever （DF） is an acute infectious disease caused by the dengue virus （DENV）. Currently，the clinical management of DF in China follows the National Guidelines for the Diagnosis and Treatment of Dengue Fever， which primarily consists of supportive care. Neither specific antiviral drugs nor universally approved vaccines are available. This article elaborates on the practical application and clinical insights of the six-meridian syndrome differentiation theory of Shang Han Lun （Treatise on Cold Damage） in the diagnosis and treatment of DF. By analyzing the onset characteristics of DF in patients，this article proposes that its core traditional Chinese medicine pathogenesis is "latent pathogen erupting externally into the three yang meridians while sinking internally into the three yin meridians." The resulting patterns include overlap of diseases of taiyang and shaoyang，triple-yang combination of diseases，and taiyang-shaoyang-taiyin combination of diseases，among others. Classical formulas such as Chaihu Guizhi Decoction are therefore widely applied in clinical practice.