Abstract：This article is to introduce Director CAO Xuemei's clinical experience in treating depression with static and dynamic spirit-regulating method based on the "unity of body and spirit" theory. Director CAO holds that the core pathogenesis of depression is initiated by liver qi stagnation， leading to qi-movement disharmony of the conception vessel and governor vessel （qi stagnation in the conception vessel and qi deficiency in the governor vessel） as the structural basis，and yin-yang imbalance in the heart，liver，and kidney as the key aspect of mental disease，forming a vicious cycle of "mutual damage of body and spirit". Director CAO Xuemei established the "static and dynamic spiritregulating method" （regulating conception vessel and unblocking governor vessel by acupuncture，low and moderateintensity aerobic exercise， and Dantian breathing exercises） under the guidance of "nourishment of body and spirit". This approach achieves simultaneous treatment of body and spirit by regulating conception vessel and unblocking governor vessel，balancing yin and yang，nourishing the zang-fu organs，and calming the heart and mind.