基于数据挖掘分析中医药治疗眼底出血用药规律
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R276.7

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国家自然科学基金青年科学基金项目(82405485);广东省中医院院内专项课题(YN2023WSSQ06);廖品正学术经验传承工作室(GYDSPF006)


Analysis of Medication Rules of Chinese Medicine in Treating Fundus Hemorrhage Based on Data Mining
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    摘要:

    目的:基于中医传承辅助平台v3.5挖掘分析中医药治疗眼底出血的用药规律。方法:检索中国知 识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP) 1995年1月至2025年 5月治疗眼底出血的中医处方,利用中医传承辅助平台v3.5进行用药频数、性味归经、关联规则分析、聚类分 析。结果:共纳入处方270首,涉及证型69个,其中主要证型为:气滞血瘀证、肝肾阴虚证、阴虚燥热证、痰 瘀阻络证、气阴两虚证。中药247味,高频药物有生地黄、当归、丹参、赤芍、川芎、三七等;药性以寒、温 为主;药味以甘、苦、辛味为主;归经以肝经、心经、脾经、肾经为主。将关联规则分析及k-means聚类算法 与回归模型结合,得到5首核心药物组合及1首新处方。结论:中医治疗眼底出血侧重以活血化瘀、凉血止血、 滋补肝肾为主,常选用活血化瘀、凉血止血、益气通络、补益肝肾的药物,典型方剂如血府逐瘀汤、补阳还 五汤。

    Abstract:

    Abstract:Objective:To analyze the medication rules of Chinese medicine in the treatment of fundus hemorrhage based on the Traditional Chinese Medicine Inheritance Support System v3.5. Methods:Chinese medicine prescriptions for fundus hemorrhage were retrieved from the China National Knowledge Infrastructure (CNKI), WanFang Data Knowledge Service Platform (WanFang), and China Science and Technology Journal Database (VIP) from January 1995 to May 2025. The Traditional Chinese Medicine Inheritance Support System v3.5 was used to analyze herb frequency,nature,flavors,meridian tropism,association rules,and clustering. Results:A total of 270 prescriptions were included,involving 69 syndrome types,with the main ones being qi stagnation and blood stasis syndrome,liverkidney yin deficiency syndrome, yin deficiency with dry-heat syndrome, phlegm-stasis obstructing collateral syndrome, and qi-yin deficiency syndrome. There were 247 Chinese herbs, with high-frequency herbs including Rehmanniae Radix, Angelicae Sinensis Radix, Salviae Miltiorrhizae Radix et Rhizoma, Paeoniae Radix Rubra, Chuanxiong Rhizoma,and Notoginseng Radix et Rhizoma. Herb nature was predominantly cold and warm;flavors were mainly sweet, bitter, and pungent; and meridian tropism primarily involved the liver, heart, spleen, and kidney meridians. By combining association rule analysis,k-means clustering algorithm,and regression modeling,five core herb combinations and one new prescription were derived. Conclusion: Chinese medicine treatment of fundus hemorrhage emphasizes invigorating blood and dissolving stasis,cooling blood to arrest bleeding,and nourishing the liver and kidney. Commonly selected herbs include those for invigorating blood and dissolving stasis,cooling blood to arrest bleeding, tonifying qi and unblocking collaterals, and tonifying the liver and kidney. Representative formulas include Xuefu Zhuyu Decoction and Buyang Huanwu Decoction.

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郭子怡,胡方欣,王燕,王璐,林婉儿,庞龙.基于数据挖掘分析中医药治疗眼底出血用药规律[J].新中医,2026,58(5):7-13

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  • 在线发布日期: 2026-03-12
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