Abstract：Objective：To observe the effect of Jianpi Zhixie Decoction combined with Sanzijing school tuina and conventional therapy in treating children with protracted diarrhea of spleen deficiency type. Methods ： A total of 122 children with protracted diarrhea of spleen deficiency type admitted to the First Affiliated Hospital of Henan University of Chinese Medicine between January 2021 and August 2024 were selected and randomly divided into the control group and the trial group via a random number table method， with 61 cases in each group. Both groups received conventional symptomatic supportive therapy and Sanzijing school tuina therapy. The trial group was additionally treated with Jianpi Zhixie Decoction. Treatment duration was one week for both groups. Traditional Chinese medicine （TCM） syndrome scores were evaluated before and after treatment. Immune function indicators [immunoglobulin （Ig） G， IgA， CD8+ ， CD4+ ， CD4+/CD8+ ratio] and inflammatory factor indicators [tumor necrosis factor-α（ TNF-α），procalcitonin（ PCT），high-sensitivity C-reactive protein（ hs-CRP），interleukin-6（ IL-6）] were measured. The time to diarrhea disappearance，time to normal stool restoration，time to dehydration correction，and hospitalization duration were recorded. Clinical effects and incidence of adverse reactions were compared between the two groups. Results：After one week of treatment，the total effective rate in the trial group was higher than that in the control group （P＜0.05）. The time to diarrhea disappearance， time to normal stool restoration， time to dehydration correction，and hospitalization duration in the trial group were shorter than those in the control group （P＜0.05）. Scores for stool frequency，stool consistency，spiritlessness，anorexia，and facial complexion were decreased in both groups after treatment when compared with those before treatment （P＜0.05），and the five TCM syndrome scores in the trial group were lower than those in the control group （P＜0.05）. Levels of IgG，IgA，CD4+，and the CD4+/CD8+ ratio were increased in both groups after treatment，while CD8+ levels were decreased （P＜0.05）. The trial group showed higher levels of IgG，IgA，CD4+，and CD4+/CD8+ ratio，and lower CD8+ levels than the control group （P＜0.05）. Levels of TNF-α，PCT，hs-CRP，and IL-6 were decreased in both groups after treatment （P＜0.05），and these levels in the trial group were lower than those in the control group （P＜0.05）. No significant difference was found in the incidence of adverse reactions between the two groups （P＞0.05）. Conclusion：Based on conventional therapy and Sanzijing school tuina，the addition of Jianpi Zhixie Decoction in the treatment of children with protracted diarrhea of spleen deficiency type can effectively improve immune function， alleviate inflammatory response， promote the improvement of clinical symptoms，shorten hospitalization time，and demonstrate good safety.