Abstract：Objective：To observe the effect of tiger-figured copper scraping on negative emotions and quality of life in liver failure patients undergoing artificial liver therapy. Methods：A total of 160 liver failure patients admitted to the the First Affiliated Hospital of Henan University of Chinese Medicine from January 2020 to December 2024 were selected as study subjects. They were randomly divided into the control group and the observation group using the random number table method，with 80 cases in each group. During the trial，one patient in the control group requested early withdrawal due to allergy. Finally，79 and 80 cases were included in the control and observation groups，respectively. The control group received artificial liver therapy and routine nursing care based on their condition. The observation group received additional tiger-figured copper scraping on the basis of the control group's treatment. Liver function， coagulation function，emotional state，and quality of life were compared between the two groups，and the incidence of adverse reactions was recorded. Results： After treatment， levels of alanine aminotransferase （ALT）， aspartate aminotransferase（ AST），and total bilirubin（ TBIL） decreased in both groups compared to before treatment（ P＜0.05）. However，there was no statistically significant difference in ALT，AST，and TBIL levels between the two groups after treatment （P＞0.05）. After treatment， thrombin time （TT）， prothrombin time （PT）， and activated partial thromboplastin time （APTT） shortened， and fibrinogen （FIB） levels decreased in both groups compared to before treatment （P＜0.05）. Furthermore，the observation group showed shorter TT，PT，and APTT，and lower FIB levels than the control group （P＜0.05）. After treatment， the Self-Rating Anxiety Scale （SAS） scores and the Self-Rating Depression Scale （SDS） scores decreased in both groups compared to before treatment （P＜0.05）. Moreover，SAS and SDS scores in the observation group were lower than those in the control group （P＜0.05）. One month after treatment， scores across all dimensions and the total score of the 36-Item Short Form Health Survey （SF-36） increased in both groups compared to before treatment （P＜0.05）. Additionally， the observation group had higher SF-36 dimension scores and total score than the control group （P＜0.05）. The incidence of adverse reactions in the observation group was 2.50%，lower than that of 13.92% in the control group （P＜0.05）. Conclusion：Tiger-figured copper scraping helps improve coagulation function，alleviate anxiety and depression，enhance quality of life，and reduce the incidence of adverse reactions in liver failure patients undergoing artificial liver therapy.