Abstract：Objective：To analyze the medication patterns of Chinese medicine in treating atrial fibrillation （AF） using data mining technology and explore the mechanism of core herbal combinations through network pharmacology. Methods： Clinical randomized controlled trial （RCT） literature on Chinese medicine treatment of AF was retrieved from CNKI and other public databases. Cluster analysis，association rule analysis，and complex network analysis were performed on the included prescriptions to identify core herbal combinations. Active ingredients and targets of core herbs were obtained from TCMSP， ETCM， and BATMAN-TCM databases， while disease targets were collected from GeneCards， OMIM， and DisGeNET. Protein-protein interaction （PPI） networks were constructed using the STRING database， and core targets were screened with Cytoscape. Gene Ontology （GO） functional enrichment and Kyoto Encyclopedia of Genes and Genomes （KEGG） pathway analyses were conducted on overlapping targets using the OmicShare platform， followed by molecular docking verification. Results： High-frequency herbs included Ophiopogonis Radix，Salviae Miltiorrhizae Radix，Glycyrrhizae Radix et Rhizoma Praeparata cum Melle，Schisandrae Chinensis Fructus，and Rehmanniae Radix. Association rules indicated frequent use of tonifying herbal combinations， and cluster analysis identified five categories. The core herbal combination predicted by complex network analysis was Ophiopogonis Radix，Schisandrae Chinensis Fructus，Glycyrrhizae Radix et Rhizoma Praeparata cum Melle，Salviae Miltiorrhizae Radix，Rehmanniae Radix，Cinnamomi Ramulus，and Ginseng Radix. Key active ingredients included tanshinone， catalpol， liquiritin cinnamaldehyde， and kaempferol. A total of 1 049 drug targets and 4 657 disease targets were identified， with 520 overlapping targets. Core targets included CALM3， NPPA， MAPK1， AKT1， and IL-6. GO analysis revealed biological processes such as response to oxygen-containing compounds and regulation of lipid metabolism. KEGG analysis highlighted enrichment in AGE-RAGE， IL-17， and Ras signaling pathways. Molecular docking confirmed stable binding between five main active components and five key targets. Conclusion： Chinese medicine treatment of AF frequently uses tonifying herbs， with emphasis on nourishing yin， boosting qi， clearing heat，and cooling blood. The core herbal combination may treat AF by acting on CALM3，NPPA，MAPK1， AKT1，and IL-6 targets through components like tanshinone，catalpol，liquiritin，cinnamaldehyde，and kaempferol， regulating AGE-RAGE， IL-17， and Ras signaling pathways， thereby modulating inflammatory response， antimyocardial fibrosis，and anti-cardiac remodeling.