基于数据挖掘分析王亿平治疗肾性蛋白尿用药规律
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R696+.2;R256.59

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国家中医优势专科(国中医药医政函〔2024〕90号);合肥市关键共性技术研发(生命健康专项:GJ2022SM03);安徽省重大疑难疾病中西协同攻关项目(皖中医药发展秘〔2021〕70号)


Analysis of Medication Rules of WANG Yiping in Treating Renal Proteinuria Based on Data Mining
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    摘要:

    目的:基于数据挖掘分析王亿平教授治疗肾性蛋白尿的用药规律。方法:收集2023年12月1日— 2024年12月1日就诊于王亿平教授门诊的肾性蛋白尿病案,使用Excel 2016将其中药处方构建病例资料数据 库,统计中药的四气、五味、归经分布及使用频次,使用IBM SPSS Modeler 18进行数据挖掘的关联规则分析, 并采用IBM SPSS Statistics 27.0进行聚类分析,使用Cytoscape 3.10进行核心药物复杂网络分析,总结分析王亿 平教授治疗肾性蛋白尿临床用药规律及学术思想。结果:共收集病案269例,处方196首,涉及中药158味, 药物使用总频次3 938次,药物使用频次居前10位的中药依次为黄芪、白术、茯苓、丹参、党参、山茱萸、熟 地黄、薏苡仁、五味子、莲子;药物功效以补肺健脾益肾、固摄精微、活血化瘀类为主;四气以温为主,平 性次之;五味以甘味居多,苦味次之。归经以脾、肾、肺经为主,脾经占比最大。关联规则分析得到18个关 联药组,聚类分析得出3个核心类方,核心药物复杂网络分析提示王亿平教授治疗肾性蛋白尿以补肺健脾益 肾、固摄精微类药物为组方核心。结论:王亿平教授辨治肾性蛋白尿有以补肺健脾益肾、固摄精微、活血化 瘀类药物为主,甘、苦合用的用药规律,体现了以三焦失调为核心病机,以补肺健脾益肾为主要治法,重视 固涩、化瘀,强调三焦同治的学术思想。

    Abstract:

    Abstract: Objective: To analyze the medication rules of Professor WANG Yiping in treating renal proteinuria based on data mining. Methods: The medical records of renal proteinuria in Professor WANG Yiping's outpatient department from December 1, 2023 to December 1, 2024 were collected. Excel 2016 was used to construct a case data database for Chinese medicine prescriptions, and the distribution and frequency of four qi, five flavors and meridian tropisms of Chinese medicine were counted.IBM SPSS Modeler 18 was used to analyze the association rules of data mining,IBM SPSS Statistics 27.0 was used for cluster analysis,and Cytoscape 3.10 was used for complex network analysis of core Chinese medicines.The clinical medication rules and academic thoughts of Professor WANG Yiping in treating renal proteinuria were summarized and analyzed. Results: A total of 269 cases of medical records were collected,and 196 prescriptions for patients, involving 158 Chinese medicines. Their total frequency of use was 3 938 times. The top 10 Chinese medicines were Astragali Radix, Atractylodis Macrocephalae Rhizoma, Poria, Salviae Miltiorrhizae Radix et Rhizoma, Codonopsis Radix, Corni Fructus, Rehmanniae Radix Praeparata, Coicis Semen,Schisandrae Chinensis Fructus,and Nelumbinis Semen;their efficacy was mainly for tonifying the lung and invigorating the spleen and kidney,consolidating essence,and promoting blood circulation and removing blood stasis; their four qi were mainly warm,followed by neutral;the five flavors were mostly sweet,followed by bitter.The main meridian tropisms were the spleen, kidney, and lung meridians, and the spleen meridian accounted for the largest proportion. Through association rule analysis, 18 associated medicinal groups were obtained, and three core class prescriptions were obtained by cluster analysis.The complex network analysis of core Chinese medicines suggested that Professor WANG Yiping's treatment of renal proteinuria was based on the core Chinese medicines for tonifying the lung and invigorating the spleen and kidney, and consolidating essence in prescriptions. Conclusion: Professor WANG Yiping's treatment of renal proteinuria follows a medication rules centered on Chinese medicines that tonify the lung, invigorate the spleen and kidney,along with those for consolidating essence and activating blood and resolving stasis, combining sweet and bitter flavors. This medication rule reflects his academic thought,which identifies the imbalance of the triple energizer as the core pathogenesis,adopts tonifying the lung,invigorating the spleen and kidney as the main treatment methods, emphasizes arresting discharge and removing blood stasis, and highlights the simultaneous treatment of the triple energizer.

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高怡琳,指导:王亿平.基于数据挖掘分析王亿平治疗肾性蛋白尿用药规律[J].新中医,2026,58(6):1-6

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  • 在线发布日期: 2026-03-31
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