Abstract：Objective：To observe the efficacy of modified Xiaochaihu Decoction and Sangju Decoction combined with oseltamivir in treating influenza in children．Methods：A total of 80 children with influenza diagnosed and treated at Lishui People's Hospital from October 2021 to October 2024 were selected and divided into an oseltamivir group and a combination group according to the treatment method， with 40 cases in each group． The oseltamivir group received oseltamivir treatment， while the combination group received modified Xiaochaihu Decoction and Sangju Decoction in addition to oseltamivir． Both groups were treated for seven days. Clinical efficacy， disappearance time of primary symptoms，incidence of adverse reactions，and levels of immune function indicators [CD3+，CD4+，CD8+，CD4+/CD8+ ratio] and inflammatory factors [tumor necrosis factor-α（ TNF-α），interferon-γ（ IFN-γ），C-reactive protein（ CRP）， interleukin-6（ IL-6）] before and after treatment were compared between the two groups. Results：After treatment，the total effective rate was 97.50% （39/40） in the combination group and 85.00% （34/40） in the oseltamivir group，with a significant difference between the two groups （P＜0.05）. After treatment， the disappearance times of sore throat， cough， and fever in the combination group were shorter than those in the oseltamivir group， with significance in differences （P＜0.05）. After three days of treatment， the levels of CD3+ ， CD4+ ， and CD4+/CD8+ ratio increased in both groups compared with those before treatment （P＜0.05）， while CD8+ levels decreased （P＜0.05）. The combination group showed higher levels of CD3+，CD4+，and CD4+/CD8+ ratio than the oseltamivir group （P＜0.05）， and lower CD8+ levels than the oseltamivir group （P＜0.05）． After three days of treatment， the levels of TNF-α， IFN- γ， CRP， and IL-6 decreased in both groups compared with those before treatment （P＜0.05）， and the combination group had lower levels of these inflammatory factors than the oseltamivir group （P＜0.05）. During treatment，the incidence of adverse reactions was 22.50% （9/40） in the combination group and 20.00% （8/40） in the oseltamivir group， with no significant difference between the two groups （P＞0.05）. Conclusion： Modified Xiaochaihu Decoction and Sangju Decoction combined with oseltamivir is significantly effective in treating influenza in children. It can improve the body's inflammatory response， enhance immune function， promote the resolution of clinical symptoms，and exhibit a favorable safety profile.