金匮肾气丸联合布地奈德福莫特罗粉吸入剂治疗肾阳虚型支气管哮喘临床研究
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R256.12;R562.2+5

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Clinical Study on Jingui Shenqi Pills Combined with Budesonide Formoterol Powder Inhalation for Bronchial Asthma with Kidney Yang Deficiency Type
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    摘要:

    目的:观察金匮肾气丸联合布地奈德福莫特罗粉吸入剂治疗肾阳虚型支气管哮喘的临床疗效。方 法:选取2021年6月—2023年2月期间丽水市人民医院收治的80例肾阳虚型支气管哮喘患者,采用随机数字 表法分成治疗组与对照组,每组40例。对照组给予布地奈德福莫特罗粉吸入剂治疗,治疗组在对照组治疗基 础上加用金匮肾气丸治疗。比较2 组临床疗效、不良反应、中医证候评分、肺功能指标[呼气峰值流 速(PEF)、第1秒用力呼气容积(FEV1) 以及FEV1/用力肺活量(FVC)]、成人哮喘生活质量评分表(AQLQ) 评分。结果:治疗组总有效率为92.50% (37/40),对照组为75.00% (30/40),2 组比较,差异有统计学意 义(P<0.05)。治疗后,2组主、次症中医证候评分及总分均较治疗前降低(P<0.05),且治疗组主、次症中 医证候评分及总分均低于对照组(P<0.05)。治疗后,2组PEF、FEV1、FEV1/FVC水平均较治疗前上升(P< 0.05),且治疗组上述各项指标均高于对照组(P<0.05)。治疗后,2组AQLQ量表中心理状况、对自身健康关 心、活动受限、刺激反应及哮喘症状评分均较治疗前上升(P<0.05),且治疗组上述各项评分均高于对照 组(P<0.05)。治疗过程中,治疗组不良反应发生率为2.50% (1/40),对照组为20.00% (8/40),2组比较, 差异有统计学意义(P<0.05)。结论:金匮肾气丸联合布地奈德福莫特罗粉吸入剂能够改善肾阳虚型支气管哮 喘患者肺功能以及中医证候,降低不良反应发生率,提高临床疗效和生活质量。

    Abstract:

    Abstract: Objective: To observe the clinical efficacy of Jingui Shenqi Pills combined with Budesonide Formoterol Powder Inhalation for bronchial asthma with kidney yang deficiency type. Methods : A total of 80 cases of patients with bronchial asthma with kidney yang deficiency type admitted to Lishui People's Hospital from June 2021 to February 2023 were selected and divided into the treatment group and the control group according to the random number table method,with 40 cases in each group.The control group was treated with Budesonide Formoterol Powder Inhalation, and the treatment group was given Jingui Shenqi Pills in addition to the control group's treatment. The clinical efficacy, adverse reactions, traditional Chinese medicine syndrome scores, lung function indicators [peak expiratory flow (PEF),forced expiratory volume in the first second (FEV1),FEV1/forced vital capacity (FVC)],and the scores of Adult Asthma Quality of Life Questionnaire (AQLQ) were compared between the two groups.Results: The total effective rate was 92.50% (37/40) in the treatment group and 75.00% (30/40) in the control group, the difference being significant (P<0.05). After treatment,traditional Chinese medicine syndrome scores and total scores for both primary and secondary symptoms in the two groups were decreased when compared with those before treatment (P<0.05), and the scores were lower in the treatment group than in the control group (P<0.05). After treatment,the levels of PEF,FEV1,and FEV1/FVC in the two groups were increased when compared with those before treatment (P<0.05),and the above indexes were higher in the treatment group than in the control group (P<0.05). After treatment, the scores for psychological status, concern for personal health, activity limitation, stimulus responses, and asthma symptoms in the AQLQ in the two groups were elevated when compared with those before treatment (P<0.05), and the above scores were higher in the treatment group than in the control group (P<0.05). During the treatment process, the incidence of adverse reactions was 2.50% (1/40) in the treatment group and 20.00% (8/40) in the control group, the difference being significant (P<0.05). Conclusion: Jingui Shenqi Pills combined with Budesonide Formoterol Powder Inhalation for patients with bronchial asthma with kidney yang deficiency type can improve their lung function and traditional Chinese medicine syndromes, reduce the incidence of adverse reactions,and enhance clinical efficacy and quality of life.

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陈娟娟,赵青青,陈婧婧,何婷,蔡晓平,蓝蓓蕾.金匮肾气丸联合布地奈德福莫特罗粉吸入剂治疗肾阳虚型支气管哮喘临床研究[J].新中医,2026,58(6):28-32

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  • 在线发布日期: 2026-03-31
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