八珍汤联合碳酸钙D3片治疗老年股骨粗隆间骨折临床研究
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R274.12

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河南省中医药拔尖人才培养项目(2022ZYBJ22);三门峡市科技攻关项目(2022002074)


Clinical Study on Bazhen Decoction Combined with Calcium Carbonate D3 Tablets for Intertrochanteric Fracture of Femur in Elderly
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    摘要:

    目的:观察八珍汤联合碳酸钙D3片治疗老年股骨粗隆间骨折(IFF) 的临床疗效。方法:选取 2022年9月—2024年12月三门峡市中医院收治的60例老年单侧IFF住院患者,按照随机数字表法分为治疗组 和对照组各30例。2组均采用闭合复位联合股骨近端髓内钉(PFNA) 内固定术治疗,对照组术后给予碳酸钙 D3片治疗,治疗组术后给予八珍汤联合碳酸钙D3片治疗。疗程均为4周。比较2组临床疗效、并发症及不良反 应情况,以及治疗前后中医证候评分、Harris髋关节功能评分、疼痛视觉模拟评分法(VAS) 评分和C-反应蛋 白(CRP)、D-二聚体(D-D)、骨保护素(OPG)、骨钙素(BGP) 水平。结果: 治疗组总有效率为 93.33% (28/30),对照组为73.33% (22/30),组间比较,差异有统计学意义(P<0.05)。治疗后,2 组中 医证候评分、VAS评分均较治疗前降低(P<0.05),且治疗组2项评分低于对照组(P<0.05)。治疗后,2组 Harris髋关节功能评分均较治疗前升高(P<0.05),且治疗组Harris髋关节功能评分高于对照组(P<0.05)。 治疗后,2组CRP、D-D水平均较术后1天降低(P<0.05),OPG、BGP水平均较术后1天升高(P<0.05);且 治疗组CRP、D-D水平低于对照组(P<0.05),OPG、BGP水平高于对照组(P<0.05)。住院治疗期间,2组 患者均未发生皮疹、出血、呕吐等与药物相关的严重异常反应。结论:八珍汤联合碳酸钙D3片治疗老年IFF疗 效显著,可有效缓解疼痛症状,改善髋关节功能,促进骨折愈合,减轻机体炎症反应,改善凝血功能及骨代谢 水平。

    Abstract:

    Abstract: Objective: To observe the clinical effect of combination use of Bazhen Decoction and Calcium Carbonate D3 Tablets on intertrochanteric fracture of femur (IFF) in elderly.Methods:A total of 60 elderly inpatients with unilateral IFF admitted into Sanmenxia Traditional Chinese Medicine Hospital from September 2022 to December 2024 were selected and randomly divided into the treatment group and the control group according to the random number table method, with 30 cases per group. Both groups were treated with closed reduction and proximal femoral nail antirotation (PFNA) internal fixation.The control group received Calcium Carbonate D3 Tablets after surgery,and the treatment group was given both Bazhen Decoction and Calcium Carbonate D3 Tablets after surgery.The treatment course was four weeks. The clinical effects, complications, and incidence of adverse reactions, as well as the traditional Chinese medicine syndrome scores, Harris Hip scores, VAS scores, and the levels of C-reactive protein (CRP), D-Dimer (D-D), osteoprotegerin (OPG), and bone gla protein (BGP) before and after treatment were compared between the two groups. Results: The total effective rate was 93.33% (28/30) in the treatment group, higher than that of 73.33% (22/30) in the control group, the difference being significant (P<0.05). After treatment, the traditional Chinese medicine syndrome scores and VAS scores in both groups decreased when compared with those before treatment (P<0.05),and the two scores in the treatment group were lower than those in the control group (P< 0.05). After treatment, the Harris Hip scores in the two groups increased when compared with those before treatment (P<0.05), and the above scores in the treatment group were higher than those in the control group (P< 0.05).After treatment,the levels of CRP and D-D in the two groups decreased when compared with those on the first day after surgery (P<0.05),and the levels of OPG and BGP increased when compared with those on the first day after surgery (P<0.05);the levels of CRP and D-D in the treatment group were lower than those in the control group (P< 0.05),and the levels of OPG and BGP were higher than those in the control group (P<0.05). During hospitalization, no serious drug-related abnormal reactions such as rash, bleeding, and vomiting occurred in the two groups. Conclusion: The combination use of Bazhen Decoction and Calcium Carbonate D3 Tablets has a significant curative effect on IFF in the elderly,which can effectively relieve pain,improve the hip function,promote the fracture healing, reduce the body's inflammatory responses,and improve the coagulation function and bone metabolism.

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孔军,倘艳锋,茹国华,李燕.八珍汤联合碳酸钙D3片治疗老年股骨粗隆间骨折临床研究[J].新中医,2026,58(6):33-37

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  • 在线发布日期: 2026-03-31
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