Abstract： Objective： To explore the influence of the five-circuit and six-qi on the onset of type 2 diabetes mellitus（ T2DM） from the perspective of birth time-phases. Methods：A statistical analysis was performed on the fivecircuit and six-qi （namely，heavenly stems chronology，yearly circuit，celestial control，terrestrial effect，dominant qi， guest qi， and exuberance and debilitation of the five elements） from the perspective of the birth time-phases of 2 088 T2DM patients. Results： The distribution of heavenly stems chronology distribution， yearly circuit， celestial control and terrestrial effect， and dominant qi at birth time-phases among patients with T2DM showed statistically significant differences as confirmed by the chi-square test （P＜0.05）. Among them， the statistical analysis of the heavenly stems chronology distribution revealed that the number of T2DM patients was the highest during years of insufficient fire circuit and the lowest during years of excessive metal circuit. In the statistical analysis of yearly circuit distribution，the number of T2DM patients was highest when the fire circuit dominated and lowest when the metal circuit dominated. The statistical analysis of celestial control and terrestrial effect distribution showed that the number of T2DM patients was higher during periods with yangming dry metal as the celestial control and shaoyin monarch fire as the terrestrial effect，as well as during periods with jueyin wind wood as the celestial control and shaoyang ministerial fire as the terrestrial effect. In contrast，the number of T2DM patients was lowest during periods with taiyin damp earth as the celestial control and taiyang cold water as the terrestrial effect. The statistical analysis of dominant qi distribution indicated that the number of T2DM patients was highest during periods when yangming dry metal served as the dominant qi，and lowest during periods when shaoyin monarch fire acted as the dominant qi. Statistical analysis of the distribution of guest qi revealed no significant difference in the impact of its various types on the prevalence of T2DM （P＞0.05）. The distribution of the exuberance and debilitation of the five elements revealed that excess fire had the most significant impact on T2DM，while deficient fire had the least influence，and deficient earth exhibited a moderate effect on T2DM. Conclusion： The five-circuit and six-qi exert a certain influence on the onset of T2DM，among which fire has the greatest influence，followed by yangming dry metal and jueyin wind wood.