Abstract ： Objective ： To observe the clinical efficacy of Governor Vessel （GV） moxibustion combined with antibiotics in the treatment of sequelae of pelvic inflammatory disease （SPID） of cold-damp stagnation type and its effect on immunoglobulin （Ig） and complement levels． Methods： A total of 90 patients with SPID of colddamp stagnation type treated in the Department of Obstetrics and Gynecology， Jinhua TCM Hospital Affiliated to Zhejiang Chinese Medical University from January 2022 to December 2023 were selected．They were divided into three groups using the random number table method： the combination group （30 cases， 1 dropped out， 29 finally included）， the GV moxibustion group （30 cases， 2 dropped out， 28 finally included）， and the western medicine group （30 cases， 1 dropped out， 1 excluded， 28 finally included）． The western medicine group received antibiotic （Levofloxacin Tablets and Metronidazole Tablets） treatment， with medication administered continuously for 14 days starting from the 5th day of the menstrual cycle. The GV moxibustion group was treated with GV moxibustion therapy，receiving one session per week starting from the 8th day of the menstrual cycle，for a total of three sessions. The combination group received both GV moxibustion and antibiotic therapy within the same menstrual cycle. Evaluations were conducted before and after treatment，including assessment of traditional Chinese medicine syndrome scores and Visual Analog Scale （VAS） scores for pelvic pain，as well as measurements of Ig indicator （IgG，IgA，IgM） levels， complement （C3， C4） levels， uterine hemodynamic parameters [uterine artery pulsatility index （PI）， resistance index（ RI），systolic peak velocity/diastolic end velocity ratio（ S/D）]. Short-term efficacy，long-term efficacy，and the incidence of adverse reactions were compared among the three groups. Results：The total effective rates for both shortterm and long-term efficacy in the combination group were significantly higher than those in the western medicine group （P＜0.05）. The total effective rates for both short-term and long-term efficacy in the combination group were slightly higher than those in the GV moxibustion group，and the rates in the GV moxibustion group were also slightly higher than those in the western medicine group; however，these differences were not statistically significant （P＞0.05）. On day 7th of the first and second menstrual cycles after treatment， the traditional Chinese medicine syndrome scores and VAS scores of all three groups decreased compared to before treatment （P＜0.05）． The combination group had lower traditional Chinese medicine syndrome scores and VAS scores than both the GV moxibustion group and the western medicine group at the same time points （P＜0.05）．The GV moxibustion group had lower traditional Chinese medicine syndrome scores and VAS scores than the western medicine group at the same time points （P＜0.05）．On day 7th of the first menstrual cycle after treatment， the levels of IgG， IgA， IgM and the values of PI， RI， and S/D in all three groups decreased compared to before treatment （P＜0.05）， while complement C3 levels increased （P＜0.05）． The combination group had lower levels of IgG，IgA，IgM and lower PI，RI，and S/D values than both the GV moxibustion group and the western medicine group （P＜0.05），and higher complement C3 levels than both groups （P＜0.05）．The GV moxibustion group had lower levels of IgG，IgA，IgM and lower PI，RI，and S/D values than the western medicine group （P＜0.05）， and higher complement C3 levels than the western medicine group （P＜0.05）． There were no statistically significant differences in complement C4 levels within or among the three groups before and after treatment （P＞0.05）．There was no statistically significant difference in the incidence of adverse reactions among the three groups （P＞0.05）．Conclusion：GV moxibustion combined with antibiotics demonstrates good short-term and long-term efficacy for SPID of cold-damp stagnation type． It can effectively alleviate pelvic pain， regulate serum Ig and complement C3 levels，improve uterine artery blood flow perfusion，and shows a favorable safety profile.