Abstract： Objective： To evaluate the clinical efficacy of acupuncture combined with Duhuo Jisheng Decoction and the SPS spiral stabilization of spine in the treatment of shoulder periarthritis of wind-cold-dampness bi type. Methods： A total of 124 patients with shoulder periarthritis admitted to Hangzhou Xiaoshan Hospital of Traditional Chinese Medicine from August 2022 to August 2024 were selected and randomly divided into a control group （62 cases） and a study group （62 cases） according to a random number table method. The control group received acupuncture combined with Duhuo Jisheng Decoction， while the study group received additional treatment with the SPS spiral stabilization of spine based on the control group's regimen. Shoulder range of motion （including forward flexion， backward extension， adduction， and abduction）， pain intensity， shoulder function， pain mediators [including prostaglandin E2 （PGE2）， 5-hydroxytryptamine （5-HT）， and substance P （SP）]， inflammatory factor levels [calcitonin gene-related peptide （CGRP），cyclooxygenase-2 （COX-2），interleukin-2 （IL-2），and interleukin-17 （IL-17）]，traditional Chinese medicine syndrome scores （including shoulder pain，cold and heavy limbs with aversion to wind， and limited shoulder flexion and extension）， and clinical efficacy were compared between the two groups. Results：After treatment，the range of motion for forward flexion，backward extension，adduction，and abduction in both groups increased compared to before treatment，with the study group showing greater improvement than the control group，and the differences were statistically significant （P＜0.05）. The scores for shoulder pain，cold and heavy limbs with aversion to wind， limited shoulder flexion and extension， and the Visual Analogue Scale （VAS） pain scores decreased in both groups compared to before treatment， with the study group showing lower scores than the control group， and the differences were statistically significant （P＜0.05）. The Japanese Orthopaedic Association （JOA） shoulder function scores increased in both groups compared to before treatment， with the study group showing higher scores than the control group，and the differences were statistically significant （P＜0.05）. After treatment，the levels of PGE2，5-HT，SP，CGRP，COX-2，IL-2，and IL-17 decreased in both groups compared to before treatment，with the study group showing lower levels than the control group，and the differences were statistically significant （P＜0.05）. The total clinical efficacy rate in the study group was higher than that in the control group，with a statistically significant difference between the two groups （P＜0.05）. Conclusion： The clinical application of acupuncture combined with Duhuo Jisheng Decoction and the SPS spiral stabilization of spine can improve shoulder function， increase shoulder range of motion，and alleviate clinical symptoms in patients with shoulder periarthritis，demonstrating superior efficacy compared to conventional acupuncture combined with Duhuo Jisheng Decoction alone.