Abstract： Objective： Guided by the theory of "therapy customized to local conditions， " this study aims to analyze the differences in herbal prescriptions between COVID-19 prevention and treatment regimens issued in northern and southern China，elucidate the patterns of syndrome differentiation，and to investigate the mechanism of action of core herb combinations. Methods：Prevention and treatment regimens for COVID-19 from various provinces and cities were retrieved from literature databases. A database was established for statistical analysis. Data mining was conducted separately for the northern and southern regions to analyze the patterns of syndromes and herb prescriptions for COVID- 19. Network pharmacology was employed to analyze the mechanism of action of the core herbs. Results： A total of 29 regimens meeting the inclusion criteria were retrieved. In the northern region， 90 prescriptions met the criteria， involving 132 Chinese herbs. Eight core herbs with a frequency of use ≥25 times were identified. In the southern region， 109 prescriptions were included， involving 198 herbs， with 13 core herbs appearing ≥25 times. The most common syndromes identified in the northern region were internal blockage and external collapse syndrome， epidemic toxin blocking the lung syndrome， and deficiency of both qi and yin syndrome. In the southern region， the top syndromes were internal blockage and external collapse syndrome， and damp-heat accumulating in the lung syndrome. Network pharmacology analysis predicted that the key targets of the core herb combination "Ephedrae Herba-Armeniacae Semen Amarum-Glycyrrhizae Radix et Rhizoma" for treating COVID-19 were tumor necrosis factor （TNF），catalase （CAT）， and F2 isoprostane （F2）. Kyoto Encyclopedia of Genes and Genomes （KEGG） pathway enrichment analysis indicated that the top pathways primarily included the Coronavirus disease-COVID-19 signaling pathway， Fc epsilon RI signaling pathway， and Toll-like receptor （TLR） signaling pathway. Conclusion： Pathogenic dampness is a core etiological factor in COVID-19. The syndrome type in the northern regions tended to be cold pathogen blocking the lung， while the in the southern regions tended to be damp-heat obstruction. However， the critical stage in both regions commonly manifests as "internal blockage and external collapse. " The core herb combination Ephedrae Herba- Armeniacae Semen Amarum-Glycyrrhizae Radix et Rhizoma may exert therapeutic effects by acting on targets such as TNF，CAT，and F2，and regulating signaling pathways like TLR and Fc epsilon RI.