基于数据挖掘分析中医药治疗青春期多囊卵巢综合征用药规律
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R271.9

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国家自然科学基金项目(81804135);广东省基础与应用基础研究基金(2023A1515220040);国家中医药管理局全国中医学术流派传承工作室建设项目(国中医药人教函[2019]62号)


Analysis of Medication Patterns in Chinese Medicine in Treating Adolescent Polycystic Ovary Syndrome Based on Data Mining
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    摘要:

    目的:基于数据挖掘分析中医药治疗青春期多囊卵巢综合征用药规律。方法:检索中国知网、万 方数据知识服务平台、维普网及中国生物医学文献数据库自建库至2025年6月30日发表的有关中医药治疗青 春期多囊卵巢综合征的临床研究及名医经验文献,筛选符合纳排标准的文献,规范药名,运用SPSS Modeler 18.0、SPSS Statistics 26.0、Microsoft Excel等统计学软件,进行证型分布、用药频次、性味归经统计,并对高 频药物进行关联规则分析及聚类分析。结果:共筛选纳入文献102篇,包含142首处方,统计出15个证型,其 中涉及肾虚的证型7个;涉及中药147味,高频药物有当归、茯苓、菟丝子等27味,药性以温、平、微寒为 主,药味以甘、苦、辛为主,归经以肝、肾、脾经为主。关联规则分析得出8个有效常用药对;聚类分析得出 4个药物组合。结论:青春期多囊卵巢综合征病机特点是肾虚为本,肝热脾湿,痰瘀互结;用药特点为甘温平 补,苦凉疏清,寒温并宜,具有蓄阳养阴,活血化浊,攻守并施的特点。

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    Abstract: Objective: To analyze the medication patterns of Chinese medicine in treating adolescent polycystic ovary syndrome (PCOS) based on data mining. Methods: Literature on clinical studies and expert experiences related to Chinese medicine treatment of adolescent PCOS published from the inception of databases to June 30,2025, was retrieved from China National Knowledge Infrastructure (CNKI) , Wanfang Data Knowledge Service Platform (Wanfang), China Science and Technology Journal Database (VIP), and the China Biology Medicine disc (CBM). Articles meeting the inclusion and exclusion criteria were screened,and herb names were standardized. Statistical analysis was performed using SPSS Modeler 18.0, SPSS Statistics 26.0, and Microsoft Excel to examine syndrome type distribution,herb frequency,properties,flavors,and meridian tropism. Association rule analysis and cluster analysis were conducted on high-frequency herbs. Results : A total of 102 articles were screened , containing 142 prescriptions and identifying 15 syndrome types, of which 7 syndrome types involved kidney deficiency. A total of 147 herbs were involved, with 27 high-frequency herbs including Angelicae Sinensis Radix, Poria, and Cuscutae Semen. Herb properties were predominantly warm, neutral, and slightly cold; flavors were mainly sweet,bitter,and pungent;and meridian tropism primarily involved the liver,kidney,and spleen meridians. Association rule analysis identified eight effective common herbal couplets; cluster analysis yielded four herb combinations. Conclusion: The pathogenesis of adolescent PCOS is characterized by kidney deficiency as the root, accompanied by liver heat,spleen dampness,and the binding of phlegm and stasis. The medication pattern features the use of sweet-warm and neutral-tonifying herbs, bitter-cool and dispersing-clearing herbs, and the appropriate combination of cold and warm herbs, exhibiting the characteristics of preserving yang and nourishing yin, activating blood circulation and resolving turbidity,and balancing reinforcement and reduction.

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罗建斐,刘莉,杨爱萍,廖慧慧,曾蕾.基于数据挖掘分析中医药治疗青春期多囊卵巢综合征用药规律[J].新中医,2026,58(7):1-7

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  • 在线发布日期: 2026-04-20
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