Abstract：Objective：To observe the effect of bone-setting and tendon-regulating therapy combined with Leihuo moxibustion on postoperative rehabilitation of osteoporotic Colles' fractures. Method： A total of 120 patients who received manual reduction combined with small splint/plaster external fixation for osteoporotic Colles' fractures in Cangnan Hospital of Traditional Chinese Medicine from January 2022 to December 2024 and were hospitalized after the operation were selected for the study. The patients were randomly divided into the control group，the Leihuo moxibustion group， and the combination group using the simple random grouping， with 40 cases in each group. All three groups received anti-osteoporosis treatment. The control group was treated with conventional rehabilitation management， the Leihuo moxibustion group was additionally intervened with Leihuo moxibustion on the basis of conventional rehabilitation， and the combination group was intervened with the bone-setting and tendon-regulating therapy on the basis of the treatment in the Leihuo moxibustion group. The changes in anatomical healing of the wrist joint，scores of pain intensity， scores of wrist joint function， and wrist joint range of motion before and after treatment， and the occurrence of complications were compared among the three groups. Result：After 4 weeks，3 months and 6 months of intervention，the heights of palmoplantar angle，ulnar deviation angle，and radius in the three groups increased when compared with those before the intervention （P＜0.05），and the heights of palmoplantar angle，ulnar deviation angle， and radius in the combination group were equal or higher than those in the control group and the Leihuo moxibustion group at the same time point （P＜0.05）. The fracture healing time of the combination group was earlier than that of the Leihuo moxibustion group and the control group （P＜0.05）. After 4 weeks，3 months and 6 months of intervention，the scores of pain intensity in the three groups were reduced when compared with those before intervention （P＜0.05），and the scores of pain intensity in the combination group were lower than those in the control group and the Leihuo moxibustion group at the same time point （P＜0.05）. After 4 weeks，3 months and 6 months of intervention，the wrist function scores of the three groups were elevated when compared with those before intervention （P＜0.05）， and the wrist function scores of the combination group were higher than those of the control group and the Leihuo moxibustion group at the same time point （P＜0.05）. After 4 weeks， 3 months and 6 months of intervention， the palm flexion， dorsiflexion， radial deviation， and ulnar deviation were all increased in the three groups when compared with those before intervention （P＜0.05）， and the palm flexion， dorsiflexion， radial deviation， and ulnar deviation in the combination group were higher than those in the control group and the Leihuo moxibustion group at the same time point （P＜0.05）. The incidence of complications was 10.0% （4/40 ） in the control group，5.0% （2/40） in the Leihuo moxibustion group，and 2.5% （1/40） in the combination group，there being no significant difference among the three groups （P＞0.05）. Conclusion： The combination use of bone-setting and tendon-regulating therapy and Leihuo moxibustion can promote the recovery of the structure of the wrist joint after osteoporotic Colles' fractures，relieve pain， improve joint function and range of motion，and accelerate healing with great safety.