基于数据挖掘分析中医药治疗帕金森病的方证及用药规律
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R256.46;R742.5

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国家自然科学基金项目(82374212,81971446);安徽省科技厅临床转化项目(202204295107020044);安徽省教育厅重点项目(2022AH050523)


Analysis of Prescription-Syndrome Type and Medication Rules in Traditional Chinese Medicine for Parkinson's Disease Based on Data Mining
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    摘要:

    目的:通过多角度数据挖掘分析中医药治疗帕金森病(PD) 的医案文献,探究其方证及用药规 律。方法:检索中国知网、维普、万方、中国生物医学文献等数据库自建库至2025年2月15日收录的相关文 献,采用Excel建立PD药物数据库,基于Lantern 5.0、Rstudio等软件对高频中药(频次≥10次) 进行隐结构模 型、综合聚类及关联规则等分析。结果:共纳入处方239首,涉及中药187味,总频次2 802次,高频药物使用 频次前5位分别为白芍、天麻、熟地黄、当归、甘草。药性主要为温、寒、平性,药味主要为甘、苦、辛味, 归经主要为肝、肾、脾经,功效分类以补虚药为主、其次为平肝熄风药。隐结构模型共得到19个隐变量、 38个隐类及5个综合聚类模型,14个核心方剂,推测PD主要证型为痰热风动、气血亏虚、髓海不足、肝肾阴 虚、血瘀风动。关联规则分析共获得18条强关联规则,其中“当归+熟地黄→白芍”组合支持度最高,“龟甲+ 牡蛎→白芍”和“当归+葛根→白芍”组合置信度最高。结论:PD以肝肾阴虚、气血不足为本,风火痰瘀为 标;治疗宜以清热化痰、益气养血为主,辅以熄风通络为法。

    Abstract:

    Abstract: Objective: To explore the prescription-syndrome type and medication rules of traditional Chinese medicine (TCM) in treating Parkinson's disease (PD) by conducting a multi-dimensional data mining analysis of relevant medical case literature. Methods: Literature published from the inception of databases including CNKI, VIP, Wanfang, and CBM until February 15, 2025, was retrieved. A PD medication database was established via Excel. High-frequency Chinese herbs (frequency≥10) were analyzed via Lantern 5.0 and Rstudio software for latent structure modeling, comprehensive clustering, and association rule mining. Results: A total of 239 prescriptions involving 187 Chinese herbs with a total frequency of 2 802 occurrences were included.The top 5 high-frequency herbs were Paeoniae Radix Alba, Gastrodiae Rhizoma, Rehmanniae Radix Praeparata, Angelicae Sinensis Radix, and Glycyrrhizae Radix et Rhizoma.Herbal natures were primarily warm,cold,and neutral;flavors were mainly sweet, bitter, and acrid; channel entries were predominantly the liver, kidney, and spleen channels. The primary effect category was deficiency-supplementing herbs, followed by liver-calming and wind-suppressing herbs. The latent structure model identified 19 latent variables,38 latent classes,and 5 comprehensive clustering models,leading to the summarization of 14 core prescriptions.The main TCM syndrome types of PD were inferred as wind stirring due to phlegm-heat,qi and blood deficiency,insufficiency of the marrow sea,yin deficiency of the liver and kidney,and wind stirring due to blood stasis.Association rule analysis yielded 18 strong rules.The rule "Angelicae Sinensis Radix + Rehmanniae Radix Praeparata → Paeoniae Radix Alba" had the highest support,while the rules "Testudinis Carapax et Plastrum+Ostreae Concha → Paeoniae Radix Alba" and "Angelicae Sinensis Radix + Puerariae Lobatae Radix→ Paeoniae Radix Alba" had the highest confidence. Conclusion: The pathogenesis of PD is characterized by a root deficiency (yin deficiency of the liver and kidney,qi and blood deficiency) and branch excess (wind,fire,phlegm, stasis).The treatment should focus on clearing heat,resolving phlegm,boosting qi,and nourishing blood,assisted by suppressing wind and unblocking collaterals.

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肖鑫,夏泽华,何蕾,宋雨梦,王凤赢,周欢,韩辉.基于数据挖掘分析中医药治疗帕金森病的方证及用药规律[J].新中医,2026,58(8):1-8

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  • 在线发布日期: 2026-04-29
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