基于数据挖掘分析张颖治疗寻常型银屑病用药规律
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R275;R758.63

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云南省滇南医学流派专项项目(XYLH202336);云南省中医临床优秀人才研修项目


Data Mining-Based Analysis of Medication Rules in ZHANG Ying's Treatment of Psoriasis Vulgaris
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    摘要:

    目的:基于数据挖掘分析云南省名中医张颖教授治疗寻常型银屑病的用药规律。方法:收集张颖 教授治疗寻常型银屑病的病例资料,运用中医传承辅助平台V2.5建立数据库,利用软件统计报表功能对药物 使用频次、四气、五味、归经进行统计分析,通过关联规则分析、聚类分析进行组方规律及新方分析的数据挖 掘,将所得结果生成图表并进行网络可视化展示。结果:筛选临床治疗寻常型银屑病处方261 首,涉及 126味药物。其中,使用频次>100次的药物有10味,分别为杏仁、甘草、干姜、白术、鸡内金、山楂、茯苓、 桔梗、黄芪、威灵仙;四气以温为主;五味以辛、甘为主;归经以脾、肺、胃经为主。基于关联规则分析得出 治疗寻常型银屑病的核心物组合使用频次≥100 次的药物组合22 组;通过复杂系统熵聚类分析挖掘出潜在 新方3首。结论:张颖教授临床治疗寻常型银屑病不拘泥于以往固有证型,结合疾病临床特点,以扶阳为本, 又不滥用温补,兼活血养阴,辨证论治。

    Abstract:

    Abstract: Objective: To analyze the medication rules of Professor ZHANG Ying, a renowned traditional Chinese medicine (TCM) expert in Yunnan Province, in the treatment of psoriasis vulgaris based on data mining. Methods: Case data of psoriasis vulgaris treated by Professor ZHANG Ying were collected. The Traditional Chinese Medicine Inheritance Support system V2.5 was used to establish a database. Statistical functions of the software were applied to analyze the frequency, four properties, five flavors, and channel entries of the herbs. Data mining for prescription rules and new prescription analysis through association rule analysis and cluster analysis was performed,and the results were presented in charts and network visualizations. Results: A total of 261 prescriptions for the clinical treatment of psoriasis vulgaris were screened,involving 126 herbs. Ten herbs were used with a frequency over 100 times: Armeniacae Semen Amarum, Glycyrrhizae Radix et Rhizoma, Zingiberis Rhizoma, Atractylodis Macrocephalae Rhizoma,Galli Gigerii Endothelium Corneum,Crataegi Fructus,Poria,Platycodonis Radix,Astragali Radix,and Clematidis Radix et Rhizoma. In terms of the four properties,the herbs were mainly warm. In terms of the five flavors, they were mainly acrid and sweet. In terms of channel entries, they were mainly the spleen, lung, and stomach channels. Based on association rule analysis,22 core herbal combinations with a usage frequency ≥100 were identified for the treatment of psoriasis vulgaris. Through entropy-based clustering analysis of complex systems, three potential new prescriptions were excavated. Conclusion: In clinical treatment of psoriasis vulgaris, Professor ZHANG Ying does not rigidly adhere to conventional syndrome types. By integrating the clinical characteristics of the disease, she focuses on supporting yang as the foundation, avoids misuse of warm-supplementing herbs, combines invigorating blood and nourishing yin,and applies syndrome differentiation-based treatment.

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段海萍,赵凤琼,陆单单,刘静琳,邓雪,邓雄飞,杨贤英,张颖.基于数据挖掘分析张颖治疗寻常型银屑病用药规律[J].新中医,2026,58(8):15-19

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  • 在线发布日期: 2026-04-29
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