麻杏石甘汤合桑白皮汤辅助西药治疗支气管肺炎痰热壅肺证临床研究
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R256.1;R563.1+2

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北京市卫生健康委员会首都卫生发展科研专项2024年立项项目(首发2024-1-5021)


Clinical Study on Maxing Shigan Decoction Plus Sangbaipi Decoction as an Adjunctive Treatment to Western Medicine for Bronchopneumonia with Accumulation of Phlegm- Heat in Lung Syndrome
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    摘要:

    目的:观察麻杏石甘汤合桑白皮汤辅助西药治疗支气管肺炎痰热壅肺证的临床疗效。方法:选取 2022年10月—2024年10月在中国人民解放军总医院第七医学中心中医科治疗的100例支气管肺炎痰热壅肺证 患者,以随机数字表法分为对照组和观察组各50例。研究过程中2组各脱落1例。对照组予西药治疗,观察组 在对照组基础上予麻杏石甘汤合桑白皮汤治疗。2组均治疗2周。比较2组临床疗效、不良反应发生率以及治 疗前后的中医证候积分、炎症指标[C-反应蛋白(CRP)、白细胞介素-6(IL-6)、干扰素-γ(IFN-γ)]、氧 化应激指标[丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px) ] 和肺功能指标[第1 秒用力呼气容 积(FEV1)、用力肺活量(FVC)、呼气峰值流速(PEF)]。结果:治疗2周后,观察组总有效率高于对照 组(P<0.05)。2组中医证候积分均较治疗前下降(P<0.05),观察组中医证候积分低于对照组(P<0.05)。 2组血清CRP、IL-6、IFN-γ、MDA水平均较治疗前下降(P<0.05),观察组血清CRP、IL-6、IFN-γ、MDA 水平均低于对照组(P<0.05)。2组血清GSH-Px水平均较治疗前升高(P<0.05),观察组血清GSH-Px水平高 于对照组(P<0.05)。2组FEV1、FVC、PEF值均较治疗前升高(P<0.05),观察组3项肺功能指标均高于对照 组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:麻杏石甘汤合桑白皮汤辅助 西药治疗支气管肺炎痰热壅肺证可提高疗效,缓解患者的临床症状,减轻炎症反应及氧化应激损伤,改善肺功能。

    Abstract:

    Abstract:Objective:To observe the clinical efficacy of Maxing Shigan Decoction plus Sangbaipi Decoction as an adjunctive treatment to western medicine for bronchopneumonia with accumulation of phlegm-heat in lung syndrome. Methods:A total of 100 patients with bronchopneumonia with accumulation of phlegm-heat in lung syndrome,treated in the Department of Traditional Chinese Medicine,the Seventh Medical Center of the Chinese PLA General Hospital from October 2022 to October 2024, were selected and randomly divided into the control group and the observation group using the random number table method, with 50 cases in each group. One case dropped out from each group during the study. The control group received western medicine treatment,while the observation group received Maxing Shigan Decoction plus Sangbaipi Decoction in addition to the control group's treatment. Both groups were treated for two weeks. Clinical efficacy, incidence of adverse reactions were compared between the two groups. Traditional Chinese medicine syndrome scores, inflammatory markers [C-reactive protein (CRP), interleukin-6 (IL-6), interferon- γ (IFN-γ)], oxidative stress indicators [malondialdehyde (MDA), glutathione peroxidase (GSH-Px)], and lung function indicators [forced expiratory volume in one second (FEV1), forced vital capacity (FVC), peak expiratory flow (PEF)] before and after treatment were compared between the two groups. Results:After two weeks of treatment, the total effective rate in the observation group was higher than that in the control group (P<0.05). Traditional Chinese medicine syndrome scores decreased in both groups compared with those before treatment (P<0.05),and the score in the observation group was lower than that in the control group (P<0.05). Serum levels of CRP,IL-6,IFN-γ,and MDA decreased in both groups compared with those before treatment (P<0.05), and the levels in the observation group were lower than those in the control group (P<0.05). Serum GSH-Px levels increased in both groups compared with those before treatment (P<0.05), and the level in the observation group was higher than that in the control group( P<0.05). Values of FEV1,FVC,and PEF increased in both groups compared with those before treatment( P< 0.05), and the values of these three lung function indicators in the observation group were higher than those in the control group (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion:Maxing Shigan Decoction plus Sangbaipi Decoction as an adjunctive treatment to western medicine for bronchopneumonia with accumulation of phlegm-heat in lung syndrome can improve efficacy, alleviate clinical symptoms,reduce inflammatory response and oxidative stress,and enhance lung function.

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孟小庆,查青山,全燕燕.麻杏石甘汤合桑白皮汤辅助西药治疗支气管肺炎痰热壅肺证临床研究[J].新中医,2026,58(8):28-34

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  • 在线发布日期: 2026-04-29
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