畲药活血降压汤治疗痰瘀互结型H 型高血压疗效观察
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R255.3;R544.1

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Observation on the Efficacy of She Medicine Huoxue Jiangya Decoction in the Treatment of H-Type Hypertension of Phlegm Blended with Blood Stasis Type
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    摘要:

    目的:观察畲药活血降压汤治疗痰瘀互结型H型高血压的临床疗效。方法:选择2022年7月— 2024年6月于丽水市中医院心血管内科就诊的80例痰瘀互结型H型高血压患者,根据信封法随机分为对照组、 畲药组各40例,对照组予以常规西医降压药与叶酸双联治疗,畲药组在对照组基础上加用活血降压汤治疗。 治疗4周,比较2组临床疗效及不良反应发生率,以及治疗前后中医证候评分、24 h动态血压与血压变异性水 平、臂踝脉搏波传导速度与踝臂指数、同型半胱氨酸水平。结果:治疗后,畲药组总有效率87.50%(35/40), 对照组为67.50% (27/40),2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候评分均较治疗前 降低(P<0.05),且畲药组评分低于对照组(P<0.05)。治疗后,2 组24 h 收缩压、舒张压均较治疗前降 低(P<0.05),且畲药组2项指标水平均低于对照组(P<0.05)。治疗后,2组昼夜舒张压变异性、昼夜收缩 压变异性水平均较治疗前降低(P<0.05),且畲药组4项指标水平均低于对照组(P<0.05)。治疗后,2组臂 踝脉搏波传导速度均较治疗前降低(P<0.05),且畲药组低于对照组(P<0.05);2组踝臂指数较治疗前上 升(P<0.05),且畲药组高于对照组(P<0.05)。治疗后,2组同型半胱氨酸水平较治疗前降低(P<0.05), 且畲药组明显低于对照组(P<0.05)。畲药组不良反应发生率为17.50% (7/40),对照组为22.50% (9/40), 2组比较,差异无统计学意义(P>0.05)。结论:在西药治疗的基础上,加用活血降压汤治疗痰瘀互结型H型 高血压可提高临床疗效,降低血压变异性及同型半胱氨酸水平,改善臂踝脉搏波传导速度与踝臂指数。

    Abstract:

    Abstract:Objective:To observe the clinical efficacy of She medicine Huoxue Jiangya Decoction in the treatment of H-type hypertension of phlegm blended with blood stasis type. Methods: A total of 80 patients with H-type hypertension of phlegm blended with blood stasis type who visited the Department of Cardiovascular Medicine at Lishui Hospital of Traditional Chinese Medicine from July 2022 to June 2024 were selected and randomly divided into a control group and a She medicine group (40 cases each) using the envelope method. The control group received conventional western antihypertensive drugs combined with folic acid for dual therapy,while the She medicine group was additionally treated with Huoxue Jiangya Decoction based on the control group. After four weeks of treatment,the clinical efficacy and incidence of adverse reactions were compared between the two groups,as well as the traditional Chinese medicine syndrome scores, levels of 24-hour ambulatory blood pressure and blood pressure variability, brachial-ankle pulse wave velocity and ankle-brachial index,and homocysteine levels before and after treatment. Results:After treatment, the total effective rate in the She medicine group was 87.50%( 35/40),while that in the control group was 67.50%( 27/ 40),with the difference between the two groups being significant (P<0.05). After treatment,the traditional Chinese medicine syndrome scores in both groups decreased compared with those before treatment (P<0.05),and the score in the She medicine group was lower than that in the control group (P<0.05).Both groups showed a significant decrease in 24-hour systolic and diastolic blood pressure after treatment (P<0.05),and the levels in the She medicine group were lower than those in the control group (P<0.05). The levels of day-night diastolic and systolic blood pressure variability were decreased in both groups after treatment (P<0.05), and the levels in the She medicine group were lower than those in the control group (P<0.05). Brachial-ankle pulse wave velocity was decreased in both groups after treatment (P<0.05),and the level in the She medicine group was lower than that in the control group (P<0.05). The ankle-brachial index was increased in both groups after treatment (P<0.05),and the level in the She medicine group was higher than that in the control group (P<0.05). Homocysteine levels were decreased in both groups after treatment (P<0.05), and the level in the She medicine group was significantly lower than that in the control group( P<0.05). The incidence of adverse reactions was 17.50%( 7/40) in the She medicine group and 22.50%( 9/40) in the control group,with no significant difference between the two groups (P>0.05). Conclusion:On the basis of western medicine treatment, the addition of Huoxue Jiangya Decoction can improve clinical efficacy, reduce blood pressure variability and homocysteine levels,and improve brachial-ankle pulse wave velocity and ankle-brachial index in patients with H-type hypertension of phlegm blended with blood stasis type.

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邱丽珍,陈文霖,柯淑兰,项伟忠.畲药活血降压汤治疗痰瘀互结型H 型高血压疗效观察[J].新中医,2026,58(8):62-67

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  • 在线发布日期: 2026-04-29
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