Abstract： Objective： To observe the effect of thermosensitive moxibustion combined with Qushi Chubi Prescription on inflammation factors and joint function in patients with knee osteoarthritis of cold-damp obstruction type. Methods：A total of 140 patients with knee osteoarthritis of cold-damp obstruction type treated in Shaoxing City Keqiao District Traditional Chinese Medicine Hospital Medical Alliance Central Hospital from January 2023 to February 2025 were selected and divided into the control group and the observation group according to the random number table method， with 70 cases in each group. The control group was treated with conventional western medicine， and the observation group was additionally treated with thermosensitive moxibustion combined with Qushi Chubi Prescription based on the treatment in the control group. The two groups were treated for four weeks continuously. The clinical effects， and the changes in Western Ontario and McMaster Universities Osteoarthritis Index （WOMAC） scores，Lysholm Knee Function scores，traditional Chinese medicine syndrome scores，serum levels of transforming growth factor-β1（ TGF-β 1）， tumor necrosis factor- α （TNF- α）， matrix metalloproteinase-9 （MMP-9）， osteoprotegerin （OPG）， and osteocalcin （BGP） before and after treatment were compared between the two groups. Results： After treatment， WOMAC scores and traditional Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment（ P＜0.05），and Lysholm scores were increased when compared with those before treatment（ P＜ 0.05）；the WOMAC scores and traditional Chinese medicine syndrome scores in the observation group were lower than those in the control group（ P＜0.05），and the Lysholm score was higher than that in the control group（ P＜0.05）. After treatment，the serum levels of TGF-β1，TNF-α，and MMP-9 in both groups were reduced when compared with those before treatment （P＜0.05），and the above three levels in the observation group were lower than those in the control group （P＜0.05）. After treatment，the serum levels of BGP and OPG were elevated when compared with those before treatment（ P＜0.05），and the above two levels in the observation group were higher than those in the control group（ P＜ 0.05）. The total clinical effective rate was 95.71%（ 67/70） in the observation group，higher than that of 82.86%（ 58/70） in the control group， the difference being signficant （P＜0.05）. Conclusion： The combination of thermosensitive moxibustion and Qushi Chubi Prescription can enhance the clinical effect on knee osteoarthritis of cold-damp obstruction type，which can reduce the joint inflammation and the degree of cartilage destruction，and regulate the bone metabolism indicators.