Abstract： This article introduces Professor YANG Wei's clinical experience in treating ulcerative colitis and inflammation-cancer transformation based on the theory of sweat pores and intestinal collaterals. Professor YANG believes that the sweat pores and intestinal collaterals are anatomically interrelated and functionally complementary. In physiological regulation， they work together to govern the opening， closing， entering， and exiting of qi movement， jointly accomplish the distribution and circulation of qi，blood，body fluids，and essential substances，and maintain the intestinal physiological functions of separating the clear from the turbid and transporting waste. Based on the theory of sweat pores and intestinal collaterals，the core pathogenesis of ulcerative colitis and inflammation-cancer transformation is considered to be obstruction of the sweat pores and toxins stagnating in the intestinal collaterals. Treatment is tailored according to the disease stages： in the active phase， the focus is on eliminating pathogenic excess， clearing the collaterals， and promoting the function of the sweat pores； in the remission phase， on strengthening the spleen， supplementing qi， harmonizing the collaterals， and warming the sweat pores； and in cases of prolonged unhealed conditions，on nourishing yin，invigorating blood，unblocking the collaterals，and ventilating the sweat pores.