Abstract：This article introduces Professor FANG Bin's clinical experience in treating osteosarcoma based on the theory of "yang transforms qi，yin constitutes form" from the Huang Di Nei Jing （The Yellow Emperor's Inner Classic）. Professor FANG proposes that the core pathogenesis of osteosarcoma is rooted in kidney yang deficiency as the foundation，manifested superficially by the intermingling of yin cold，phlegm，stasis，and cancerous toxins. Based on this，he has established a stage-based differentiation and treatment system：in the early stage，the principle focuses on warming and unblocking to prevent progression， primarily using modified Yanghe Decoction； in the progressive stage， emphasis is placed on warming yang， resolving toxins， and simultaneously reinforcing healthy qi and eliminating pathogens， treated with a self-formulated Wenyang Jiedu Prescription； in the post-operative period and after radiotherapy/chemotherapy，attention is given to supporting healthy qi and expelling toxins，often using modified Fuzi Lizhong Decoction combined with Bazhen Decoction；in the end stage，the focus shifts to protecting stomach qi， alleviating pain，and calming the mind. His medication features the heavy dosage of Aconiti Lateralis Radix Praeparata and skillful use of insect drugs，embodying the academic thought of warming yang to transform qi and resolving toxins to eliminate masses.