Abstract：This article introduces Professor YANG Peiqun's clinical experience in treating carotid atherosclerosis plaque based on the theory of accumulation-aggregation mass. From the perspective of Chinese medicine， Professor YANG points out that carotid atherosclerosis plaque shares high similarity with the pathogenic characteristics，etiology， and pathological factors of "accumulation-aggregation mass" in Chinese medicine，and thus can be treated based on this theory. Professor YANG believes that the fundamental pathogenesis of accumulation-aggregation mass lies in yang qi deficiency and stagnation， while the superficial manifestation is the lingering of yin pathogenic factors. In terms of treatment，he employs the methods of supplementing，dispersing，resolving，and attacking，and has developed the Tongyang Fumai Prescription derived from modified Guizhi plus Gegen Decoction， Guizhi Fuling Pills， and Didang Pills. The prescription is modified according to clinical manifestations and has achieved satisfactory therapeutic effects.