Abstract：Objective：To analyze the mechanism of national traditional Chinese medicine master SHEN Baofan's Tanyu Tongzhi Prescription in the prevention and treatment of hyperlipidemia and atherosclerosis based on network pharmacology and molecular docking technology. Methods： Active compounds of Tanyu Tongzhi Prescription were screened from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform （TCMSP）. Targets for treating hyperlipidemia and atherosclerosis were obtained by integrating databases such as TTD，DrugBank， and GeneCards. Cytoscape 3.8.2 was used to construct a drug-component-common target network. Protein-protein interaction network analysis was performed using the STRING system. GO functional enrichment analysis and KEGG pathway enrichment analysis of common targets were conducted via Metascape. Finally，molecular docking verification was performed with AutoDock software. Results：A total of 89 effective active components and 210 potential targets of Tanyu Tongzhi Prescription were obtained. After intersecting with disease targets， 124 overlapping genes were identified. Major active components included quercetin， tanshinone Ⅱ A， luteolin， and stigmasterol. Key targets included TNF， IL-6， MMP9， CASP3， and PTGS2. GO enrichment analysis showed that biological processes were mainly related to steroid hormone response and oxidative stress response. KEGG analysis highlighted important signaling pathways such as lipid and atherosclerosis， fluid shear stress and atherosclerosis， AGE-RAGE， IL-17， and TNF. Molecular docking results indicated good binding activity between the main active components and core targets. Conclusion： Effective active components in Tanyu Tongzhi Prescription， such as quercetin， tanshinone Ⅱ A， luteolin，and stigmasterol，may regulate core targets including TNF，IL-6，MMP9，CASP3，and PTGS2，thereby reducing inflammatory responses and ultimately treating hyperlipidemia and atherosclerosis.