Abstract：Chronic kidney disease-mineral and bone disorder （CKD-MBD） is one of the common complications of chronic kidney disease（ CKD），with a complex pathogenesis. Based on the original meaning of kidney governing storage in Huang Di Nei Jing （The Yellow Emperor's Inner Classic）， this study explores its internal connection with the core manifestation of CKD-MBD. It posits that the primary pathogenesis involves impaired storage functions，leading to the loss of essence and nutrient absorption， the internal generation of turbid toxins， and bone atrophy and meridian damage；this study proposes the therapeutic approach of strengthening the kidney and conserving essence，nourishing the spleen and kidney， and transforming turbidity to unblock collaterals. It further explores the theoretical basis for relevant prescriptions and medicines，aiming to provide new insights and methods for the traditional Chinese medicine prevention and treatment of CKD-MBD.