Abstract： Objective： To observe the clinical efficacy of modified Houpo Sanwu Decoction retention enema combined with somatostatin in the treatment of adhesive intestinal obstruction after laparoscopic surgery. Methods：A total of 86 patients with adhesive intestinal obstruction after laparoscopic surgery admitted to Hangzhou Linping District Hospital of Traditional Chinese Medicine were enrolled. They were randomly divided into two groups using the random number table method， with 43 cases in each group. Both groups received conventional treatment. The control group received somatostatin in addition to conventional treatment， while the observation group received modified Houpo Sanwu Decoction retention enema in addition to the treatment of the control group. Both groups were treated for three days. The changes in serum inflammatory factor and ion concentrations before and after treatment， as well as the recovery time of intestinal function and clinical efficacy ， were compared between the two groups. Results ： After treatment， the levels of serum tumor necrosis factor-alpha （TNF- α）， procalcitonin （PCT）， C-reactive protein （CRP）， and white blood cell （WBC） count in both groups decreased compared with those before treatment， and the levels of the above indicators in the observation group were lower than those in the control group， with statistically significant differences （P＜0.05）. After treatment，the concentrations of sodium ions and potassium ions in both groups increased compared with those before treatment，and the concentrations of the above two indicators in the observation group were higher than those in the control group，with statistically significant differences （P＜0.05）. After treatment， the recovery time of bowel sounds， time to flatus， and time to defecation in the observation group were shorter than those in the control group，with statistically significant differences（ P＜0.05）. The total clinical efficacy rate was 95.35%（ 41/43） in the observation group and 81.40%（ 35/43） in the control group，and the difference between the two groups was statistically significant （P＜0.05）. The observation group was superior to the control group in terms of the total clinical efficacy rate. Conclusion：Modified Houpo Sanwu Decoction retention enema combined with somatostatin in the treatment of adhesive intestinal obstruction after laparoscopic surgery can reduce inflammatory responses and promote the recovery of intestinal function，and its clinical efficacy is superior to somatostatin alone.