清热通腑合剂联合温针灸治疗胃癌术后功能性胃排空障碍临床研究
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R256.32;R735.2

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浙江省中医药科技计划项目(2023ZL090)


Clinical Study on Qingre Tongfu Mixture Combined with Warm Needle Moxibustion in Treating Functional Delayed Gastric Emptying After Gastric Cancer Surgery
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    摘要:

    目的:观察清热通腑合剂联合温针灸治疗胃癌术后功能性胃排空障碍(FDGE) 的临床疗效。方法:选取2023年1月—2024年11月就诊于杭州市中医院的90例胃癌术后FDGE患者,按照随机数字表法分为试验组和对照组各45例,治疗期间试验组剔除1例,对照组剔除2例。对照组予以西医常规治疗,试验组在对照组的基础上给予清热通腑合剂联合温针灸治疗。2组均连续治疗4周。观察2组胃管留置时间以及住院时间差异、临床疗效及不良反应发生情况,以及治疗前后中医证候评分、胃肠道功能指标[血清胃动素(MTL)、胃泌素(GAS)、胃蛋白酶原Ⅰ(PGⅠ)]、血清炎症因子[白细胞介素-6(IL-6) 及肿瘤坏死因子-α(TNF-α)]水平。结果:治疗后,试验组总有效率为88.64%(39/44),对照组为74.42%(32/43),组间比较,差异有统计学意义(P<0.05)。试验组胃管留置时间及住院时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,2组脘腹痞闷、恶心、呕吐、口干口苦、腹痛等中医证候评分均较治疗前降低,且试验组各项评分均低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组血清MTL、GAS水平均治疗前升高,且试验组2项指标水平均高于对照组;2 组血清PGⅠ水平均治疗前降低,且试验组PGⅠ水平低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组血清IL-6、TNF-α水平均较治疗前降低,且试验组2项指标水平均低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组SF-36评分均较治疗前升高(P<0.05),且试验组评分高于对照组(P<0.05)。2组治疗期间均未出现明显不良反应。结论:清热通腑合剂联合温针灸能够显著改善胃癌术后FDGE患者的胃肠功能、临床症状,降低血清炎症因子水平,促进患者术后康复。

    Abstract:

    Abstract: Objective: To observe the clinical efficacy of Qingre Tongfu Mixture combined with warm needle moxibustion in treating patients with functional delayed gastric emptying (FDGE) after gastric cancer surgery. Methods: A total of 90 patients with FDGE after gastric cancer surgery who were treated at Hangzhou Hospital of Traditional Chinese Medicine from January 2023 to November 2024 were selected and randomly divided into the trial group and the control group,with 45 cases in each group. During treatment,one case from the trial group and two cases from the control group were excluded, respectively. The control group received conventional western medicine treatment,while the trial group received additional Qingre Tongfu Mixture and warm needle moxibustion based on the control group's treatment. Both groups were treated continuously for four weeks. The differences of duration of gastric tube indwelling and hospital stay, clinical efficacy, incidence of adverse reactions, and the traditional Chinese medicine syndrome scores, gastrointestinal function indicators [serum motilin (MTL), gastrin (GAS), pepsinogen Ⅰ( PG Ⅰ)],and serum inflammatory factor levels [interleukin-6( IL-6) and tumor necrosis factor-α( TNF-α)] were observed before and after treatment. Results:After treatment,the total effective rate was 88.64% (39/44) in the trial group and 74.42% (32/43) in the control group, with significant difference between the two groups (P<0.05). The duration of gastric tube indwelling and hospital stay in the trial group were shorter than those in the control group,with significant differences (P<0.05). After treatment,traditional Chinese medicine syndrome scores (abdominal fullness, nausea, vomiting, dry and bitter mouth, abdominal pain) decreased in both groups compared to before treatment, and the scores in the trial group were lower than those in the control group,with significant differences( P<0.05). After treatment,serum MTL and GAS levels increased in both groups compared to before treatment,and the levels of these two indicators in the trial group were higher than those in the control group; serum PG Ⅰ levels decreased in both groups compared to before treatment,and the PG Ⅰ level in the trial group was lower than that in the control group, with significant differences (P<0.05). After treatment, serum IL-6 and TNF- α levels decreased in both groups compared to before treatment, and the levels of these two indicators in the trial group were lower than those in the control group, with significant differences (P<0.05). After treatment, SF-36 scores increased in both groups compared to before treatment (P<0.05),and the score in the trial group was higher than that in the control group (P< 0.05). No significant adverse reactions occurred in either group during treatment. Conclusion:Qingre Tongfu Mixture combined with warm needle moxibustion can significantly improve gastrointestinal function and clinical symptoms, reduce serum inflammatory factor levels,and promote postoperative recovery in patients with FDGE after gastric cancer surgery.

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潘迎春,林达,姚冠羽,许琼.清热通腑合剂联合温针灸治疗胃癌术后功能性胃排空障碍临床研究[J].新中医,2026,58(14):14-20

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  • 在线发布日期: 2026-07-31
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