Clinical Study on Qingre Tongfu Mixture Combined with Warm Needle Moxibustion in Treating Functional Delayed Gastric Emptying After Gastric Cancer Surgery
Abstract: Objective: To observe the clinical efficacy of Qingre Tongfu Mixture combined with warm needle moxibustion in treating patients with functional delayed gastric emptying (FDGE) after gastric cancer surgery. Methods: A total of 90 patients with FDGE after gastric cancer surgery who were treated at Hangzhou Hospital of Traditional Chinese Medicine from January 2023 to November 2024 were selected and randomly divided into the trial group and the control group,with 45 cases in each group. During treatment,one case from the trial group and two cases from the control group were excluded, respectively. The control group received conventional western medicine treatment,while the trial group received additional Qingre Tongfu Mixture and warm needle moxibustion based on the control group's treatment. Both groups were treated continuously for four weeks. The differences of duration of gastric tube indwelling and hospital stay, clinical efficacy, incidence of adverse reactions, and the traditional Chinese medicine syndrome scores, gastrointestinal function indicators [serum motilin (MTL), gastrin (GAS), pepsinogen Ⅰ( PG Ⅰ)],and serum inflammatory factor levels [interleukin-6( IL-6) and tumor necrosis factor-α( TNF-α)] were observed before and after treatment. Results:After treatment,the total effective rate was 88.64% (39/44) in the trial group and 74.42% (32/43) in the control group, with significant difference between the two groups (P<0.05). The duration of gastric tube indwelling and hospital stay in the trial group were shorter than those in the control group,with significant differences (P<0.05). After treatment,traditional Chinese medicine syndrome scores (abdominal fullness, nausea, vomiting, dry and bitter mouth, abdominal pain) decreased in both groups compared to before treatment, and the scores in the trial group were lower than those in the control group,with significant differences( P<0.05). After treatment,serum MTL and GAS levels increased in both groups compared to before treatment,and the levels of these two indicators in the trial group were higher than those in the control group; serum PG Ⅰ levels decreased in both groups compared to before treatment,and the PG Ⅰ level in the trial group was lower than that in the control group, with significant differences (P<0.05). After treatment, serum IL-6 and TNF- α levels decreased in both groups compared to before treatment, and the levels of these two indicators in the trial group were lower than those in the control group, with significant differences (P<0.05). After treatment, SF-36 scores increased in both groups compared to before treatment (P<0.05),and the score in the trial group was higher than that in the control group (P< 0.05). No significant adverse reactions occurred in either group during treatment. Conclusion:Qingre Tongfu Mixture combined with warm needle moxibustion can significantly improve gastrointestinal function and clinical symptoms, reduce serum inflammatory factor levels,and promote postoperative recovery in patients with FDGE after gastric cancer surgery.