中药热熨敷与振动排痰仪循经拍背联合常规疗法治疗痰浊壅肺型重症肺炎临床研究
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R259

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浙江省中医药科技计划项目(2024ZL627)


Clinical Study on Hot Compress with Chinese Medicine and Patting Back Along the Meridian with Vibration Expectoration Device Combined with Conventional Therapy for Severe Pneumonia of Phlegm-Turbidity Accumulating in the Lung Type
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    摘要:

    目的:观察在常规疗法基础上采用中药热熨敷联合振动排痰仪循经拍背治疗痰浊壅肺型重症肺炎患者的临床效果。方法:选取2024年1—12月浙江中医药大学附属杭州市中医院重症监护室(ICU) 收治的132例痰浊壅肺型重症肺炎患者,按照随机数字表法分为空白对照组、干预A组、干预B组、干预C组各33例,分别给予常规疗法、常规疗法联合振动排痰仪循经拍背、常规疗法联合中药热熨敷、常规疗法联合中药热熨敷与振动排痰仪循经拍背治疗,4 组均观察至患者转出ICU。比较4 组治疗前后的血气分析指标[氧合指数(PaO2/FiO2)、动脉血氧饱和度(SaO2)、二氧化碳分压(PaCO2)]、炎性因子[C-反应蛋白(CRP)、肿瘤坏死因子-α (TNF-α)、白细胞介素-6(IL-6)] 水平,以及治疗48 h内排出的痰液总量、临床症状持续时间(退热时长、肺啰音消失时长)、有创机械通气时间、ICU住院时间、病死率。结果:4组PaO2/FiO2、SaO2均随治疗时间的延长呈上升趋势,PaCO2均随治疗时间的延长呈下降趋势。4组治疗前、治疗7天后、治疗14天后的PaO2/FiO2、SaO2、PaCO2分别整体比较,差异均有统计学意义(P<0.05)。4组治疗7天、14天后的PaO2/FiO2、SaO2均较治疗前升高,PaCO2 均较治疗前下降,差异均有统计学意义(P<0.05)。4 组治疗14 天后的PaO2/FiO2、SaO2 均较治疗7天后升高,PaCO2均较治疗7天后下降,差异均有统计学意义(P<0.05)。治疗前,4 组PaO2/FiO2、SaO2、PaCO2 比较,差异均无统计学意义(P>0.05)。干预A、B、C 组治疗7 天、14 天后的PaO2/FiO2、SaO2均高于空白对照组,PaCO2均低于空白对照组,差异均有统计学意义(P<0.05)。干预C组治疗7 天、14 天后的PaO2/FiO2、SaO2 均高于干预A、B 组,PaCO2 均低于干预A、B 组,差异均有统计学意义(P<0.05)。干预A 组治疗7 天、14天后的PaO2/FiO2、SaO2、PaCO2 与干预B组比较,差异均无统计学意义(P>0.05)。干预A、B、C组48 h内排出的痰液总量均多于空白对照组,退热时长、肺啰音消失时长均短于空白对照组,差异均有统计学意义(P<0.05)。干预C组48 h内排出的痰液总量均多于干预A、B组,退热时长、肺啰音消失时长均短于干预A、B组,差异均有统计学意义(P<0.05)。干预A组48 h内排出的痰液总量、退热时长、肺啰音消失时长与干预B组比较,差异均无统计学意义(P>0.05)。干预C组的有创机械通气时间、ICU住院时间均短于空白对照组与干预A、B组(P<0.05);干预A组、干预B组、空白对照组的有创机械通气时间、ICU住院时间分别比较,差异均无统计学意义(P>0.05)。治疗7天后,4组的CRP、TNF-α、IL-6水平均较治疗前下降(P<0.05);干预A、B、C组的CRP、TNF-α、IL-6水平均低于空白对照组(P<0.05),干预 C组的CRP、TNF-α、IL-6水平均低于干预A、B组(P<0.05);干预A组的CRP、TNF-α、IL-6水平与干预B 组比较,差异均无统计学意义(P>0.05)。4组病死率比较,差异无统计学意义(P>0.05)。结论:在常规疗法基础上加用中药热熨敷联合振动排痰仪循经拍背治疗痰浊壅肺型重症肺炎患者,能有效促进排痰及临床症状消退,改善患者的肺部通气情况,减轻炎症反应,缩短机械通气时间及ICU住院时间。

    Abstract:

    Abstract: Objective: To observe the clinical efficacy of hot compress with Chinese medicine and patting back along the meridian with vibration expectoration device in the treatment of patients with severe pneumonia of phlegmturbidity accumulating in the lung type. Methods:A total of 132 patients with severe pneumonia of phlegm-turbidity accumulating in the lung type admitted to the Intensive Care Unit (ICU) of Hangzhou TCM Hospital of Zhejiang Chinese Medical University from January to December 2024 were selected. They were randomly divided into the blank control group,intervention group A,intervention group B,and intervention group C using the random number table method, with 33 cases in each group. The four groups received the following treatments, respectively: conventional therapy alone; conventional therapy combined with patting back along the meridian using a vibration expectoration device; conventional therapy combined with Chinese medicine hot compress;and conventional therapy combined with Chinese medicine hot compress and patting back along the meridian using the vibration expectoration device. Observation continued until the patients in the four groups were discharged from the ICU. Blood gas parameters [oxygenation index (PaO2/FiO2), arterial oxygen saturation (SaO2), partial pressure of carbon dioxide (PaCO2)] and levels of inflammatory factors [C-reactive protein( CRP),tumor necrosis factor-α( TNF-α),interleukin-6( IL-6)] before and after treatment,total sputum volume expelled within 48 hours,duration of clinical symptoms (time to fever resolution, time to disappearance of lung rales),duration of invasive mechanical ventilation,length of ICU stay,and mortality rate were compared among the four groups. Results:PaO₂/FiO₂ and SaO₂ in the four groups showed an increasing trend over time,while PaCO₂ showed a decreasing trend over time. There were significant differences in PaO2/FiO2,SaO2, and PaCO2 among the four groups before treatment,after 7 and 14 days of treatment (P<0.05). After 7 and 14 days of treatment, PaO2/FiO2 and SaO2 increased in all four groups compared to before treatment, while PaCO2 decreased, with significant differences (P<0.05). After 14 days of treatment, PaO2/FiO2 and SaO2 increased compared with those after 7 days of treatment, and PaCO₂ decreased compared with that after 7 days of treatment, with significant differences (P<0.05). Before treatment, there were no statistically significant differences in PaO2/FiO2, SaO2, and PaCO2 among the four groups (P>0.05). After 7 and 14 days of treatment,intervention groups A,B,and C showed higher PaO2/FiO2 and SaO2 and lower PaCO2 compared to the blank control group, with significant differences (P< 0.05). Intervention group C showed higher PaO2/FiO2 and SaO2 and lower PaCO₂ compared to intervention groups A and B at 7 and 14 days after treatment, with significant differences (P<0.05). There were no statistically significant differences in PaO2/FiO2,SaO2,and PaCO2 between intervention group A and intervention group B after 7 and 14 days of treatment( P>0.05). Intervention groups A,B,and C had greater total sputum volume expelled within 48 hours and shorter time to fever resolution and time to disappearance of lung rales compared to the blank control group, with significant differences( P<0.05). Intervention group C showed greater total sputum volume expelled within 48 hours and shorter time to fever resolution and time to disappearance of lung rales compared to intervention groups A and B,with significant differences (P<0.05).There were no significant differences in total sputum volume expelled within 48 hours, time to fever resolution, or time to disappearance of lung rales between intervention group A and intervention group B (P>0.05). Intervention group C had shorter duration of invasive mechanical ventilation and length of ICU stay compared to the blank control group and intervention groups A and B (P<0.05). There were no significant differences in duration of invasive mechanical ventilation or length of ICU stay among intervention group A, intervention group B, and the blank control group (P>0.05). After 7 days of treatment, CRP, TNF-α, and IL-6 levels decreased in all four groups compared to before treatment (P<0.05). Intervention groups A,B,and C showed lower CRP,TNF-α, and IL-6 levels than the blank control group( P<0.05),and intervention group C showed lower levels of CRP,TNF-α, and IL-6 than intervention groups A and B (P<0.05). There were no significant differences in CRP,TNF-α,or IL-6 levels between intervention group A and intervention group B (P>0.05). No significant difference was found in mortality rate among the four groups (P>0.05). Conclusion: Adding hot compress with Chinese medicine combined with patting back along the meridian using a vibration expectoration device to conventional therapy for patients with severe pneumonia of phlegm-turbidity accumulating in the lung type can effectively promote sputum expectoration and resolution of clinical symptoms, improve pulmonary ventilation, reduce inflammatory responses, and shorten the duration of mechanical ventilation and length of ICU stay.

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施耀丹,朱佳清,黄秋露.中药热熨敷与振动排痰仪循经拍背联合常规疗法治疗痰浊壅肺型重症肺炎临床研究[J].新中医,2026,58(14):73-81

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  • 在线发布日期: 2026-07-31
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