黄连温胆汤合酸枣仁汤加减联合决奈达隆治疗痰火扰心型阵发性心房颤动临床研究
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R256.21;R541.7+5

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广州市科技计划项目资助(2024A03J0057)


Clinical Study on Modified Huanglian Wendan Decoction plus Suanzaoren Decoction Combined with Dronedarone for Paroxysmal Atrial Fibrillation of Phlegm-Fire Disturbing Heart Type
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    摘要:

    目的:观察黄连温胆汤合酸枣仁汤加减联合决奈达隆治疗痰火扰心型阵发性心房颤动的临床效果。方法:回顾性选取2020年7月—2025年7月广东省中医院收治的痰火扰心型阵发性心房颤动患者109例,根据剔除标准剔除9例,最终纳入100例。按治疗方法的不同分为西医组48例和中西医结合组52例。西医组给予决奈达隆治疗,中西医结合组给予黄连温胆汤合酸枣仁汤加减联合决奈达隆治疗。比较2组临床疗效,疾病恢复情况,超声心动图指标[左心室射血分数(EF)、左心室收缩末期内径(LVESD)、左心房内径(LAD)] 及心功能血清指标[乳酸脱氢酶(LDH)、N末端B型利钠肽前体(NT-proBNP)] 水平及不良反应。结果:治疗后,中西医结合组总有效率为96.15% (50/52),西医组为81.25% (39/48),2 组比较,差异有统计学意义(P<0.05)。治疗后,2组24 h平均心室率、房颤发生次数、房颤发作时长均较治疗前降低(P<0.05),中西医结合组上述3项指标水平均低于西医组(P<0.05)。治疗后,2组EF水平均较治疗前升高(P<0.05),LVESD、LAD水平均较治疗前降低(P<0.05);中西医结合组EF水平高于西医组(P<0.05),LVESD、LAD水平低于西医组(P<0.05)。治疗后,2组LDH、NT-proBNP水平均较治疗前降低(P<0.05),中西医结合组LDH、NT-proBNP水平低于西医组(P<0.05)。治疗期间,中西医结合组不良反应发生率为17.31%(9/52),西医组为16.67%(8/48),2组比较,差异无统计学意义(P>0.05)。结论:黄连温胆汤合酸枣仁汤加减联合决奈达隆可以提高痰火扰心型阵发性心房颤动的临床疗效,改善心功能,促进疾病康复。

    Abstract:

    Abstract:Objective:To observe the clinical efficacy of modified Huanglian Wendan Decoction plus Suanzaoren Decoction combined with Dronedarone in the treatment of paroxysmal atrial fibrillation (PAF) of phlegm-fire disturbing heart type. Methods:A retrospective analysis was conducted on 109 patients with PAF of phlegm-fire disturbing heart type admitted to Guangdong Provincial Hospital of Chinese Medicine from July 2020 to July 2025. After excluding 9 cases based on exclusion criteria, 100 patients were finally enrolled. They were divided into the western medicine group (48 cases) and the integrated traditional Chinese and western medicine group (short as the integrated group, 52 cases) according to the treatment regimens. The western medicine group received Dronedarone alone, while the integrated group received modified Huanglian Wendan Decoction plus Suanzaoren Decoction combined with Dronedarone. The clinical efficacy, disease recovery, echocardiographic parameters [left ventricular ejection fraction (EF),left ventricular end-systolic diameter (LVESD),left atrial diameter (LAD)],serum cardiac function indicators [lactate dehydrogenase (LDH), N-terminal pro-brain natriuretic peptide (NT-proBNP)], and the incidence of adverse reactions were compared between the two groups. Results:After treatment,the total effective rate was 96.15% (50/52) in the integrated group and 81.25% (39/48) in the western medicine group, and the difference between the two groups was statistically significant (P<0.05). After treatment, the 24-hour average ventricular rate,frequency of atrial fibrillation,and duration of atrial fibrillation attacks decreased in both groups compared with those before treatment (P<0.05),and in the integrated group,the 24-hour average ventricular rate was lower,the frequency of atrial fibrillation was less, and the duration of atrial fibrillation attacks was shorter than those in the western medicine group (P<0.05). After treatment, EF levels increased in both groups compared with those before treatment (P<0.05), while LVESD and LAD decreased compared with those before treatment (P<0.05); the integrated group showed a higher EF level (P<0.05) and smaller LVESD and LAD (P<0.05) than the western medicine group. After treatment, LDH and NT-proBNP levels decreased in both groups compared with those before treatment (P<0.05), and the integrated group had lower levels of LDH and NT-proBNP than the western medicine group (P<0.05). During treatment,the incidence of adverse reactions was 17.31% (9/52) in the integrated group and 16.67% (8/48) in the western medicine group,with no statistically significant difference between the two groups (P> 0.05). Conclusion: Modified Huanglian Wendan Decoction plus Suanzaoren Decoction combined with Dronedarone can improve the therapeutic efficacy,enhance cardiac function,and promote disease recovery in patients with PAF of phlegm-fire disturbing heart type.

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李熙久,梁桑瑜,林家铭,陈文生,唐波炎.黄连温胆汤合酸枣仁汤加减联合决奈达隆治疗痰火扰心型阵发性心房颤动临床研究[J].新中医,2026,58(16):7-13

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  • 在线发布日期: 2026-08-23
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