Abstract： Objective： To analyze the molecular mechanism of Ginseng Radix et Rhizoma for ovarian cancer through network pharmacology and molecular docking technology. Methods： The active ingredients and predicted target of Ginseng Radix et Rhizoma were selected from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform （TCMSP） and SwissTargetPrediction. The disease targets of ovarian cancer were obtained through GeneCards，OMIM，and PharmGKB. The common targets of the predicted targets of Ginseng Radix et Rhizoma active ingredients and ovarian cancer disease targets were obtained by Venn diagram. Cytoscape 3.9.1 software was used to construct the relationship network between Ginseng Radix et Rhizoma active ingredients and ovarian cancer targets. The protein-protein interaction （PPI） network was constructed with the help of the STRING，and the network topology analysis was performed using the CytoNCA plug-in of Cytoscape 3.9.1 software to screen out the core targets. By using DAVID，Gene Ontology （GO） functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes （KEGG） pathway enrichment analysis were performed on common targets. The molecular docking technology （AutoDock Vina software） was used to verify and analyze the binding stability of Ginseng Radix et Rhizoma ingredients and core targets. Results： A total of 22 active ingredients （e. g.， kaempferol， β -sitosterol） and 222 predict targets were identified. Through the matching analysis of active ingredient targets and ovarian cancer disease targets， 90 common targets of predicted targets of Ginseng Radix et Rhizoma active ingredients and ovarian cancer disease targets were obtained. Through PPI network topology analysis， 13 core targets were finally identified， including AKT serine/ threonine kinase 1（ AKT1），cysteine-dependent aspartate-specific protease 3（ CASP3），prostaglandin-endoperoxide synthase 2 （PTGS2），tumor necrosis factor （TNF），etc. The results of GO functional enrichment analysis showed that the core targets of Ginseng Radix et Rhizoma active ingredients were significantly enriched in biological processes related to hypoxia response， inflammation regulation， and nuclear receptor signal transduction. The results of KEGG pathway enrichment analysis showed that the possible mechanism of Ginseng Radix et Rhizoma in the prevention and treatment of ovarian cancer involved 163 signaling pathways. The results of molecular docking showed that all of the 13 core targets had good binding activity with the active ingredients of Ginseng Radix et Rhizoma， and the binding affinity of frutinone A and PTGS2 was the strongest. Conclusion： Ginseng Radix et Rhizoma can act on core targets such as AKT1，CASP3，BCL2，and TNF，and regulate multiple signaling pathways to regulate tumor cell apoptosis， inflammation，and metastasis through active ingredients such as frutinone A，kaempferol，and ginsenoside Rh2.