Abstract： Objective： To observe the efficacy of yang-supporting cupping therapy combined with western medicine in treating cough of phlegm-damp accumulating in the lung type after Mycoplasma pneumoniae（ MP） infection in children. Methods： A total of 102 children with cough of phlegm-damp accumulating in the lung type after MP infection who attended the Pediatric Outpatient Clinic of Haining Hospital of Traditional Chinese Medicine from July 2024 to June 2025 were selected as study subjects. They were randomly divided into a western medicine group and a Chinese medicine group using a random number table method，with 51 cases in each group. The western medicine group received sequential Azithromycin therapy combined with nebulized Budesonide Suspension Inhalation， while the Chinese medicine group received additional yang-supporting cupping therapy based on the western medicine group's treatment. Clinical efficacy， incidence of adverse reactions， and changes in etiological indicators， inflammatory markers，and traditional Chinese medicine syndrome scores before and after treatment were compared between the two groups. Results：The total clinical efficacy rate was 96.08% （49/51） in the Chinese medicine group and 82.35% （42/ 51） in the western medicine group，with a significant difference between the two groups （P＜0.05）. After treatment， there were no significant differences in the positive rates of MP DNA，immunoglobulin G （IgG），and immunoglobulin M （IgM） between the two groups （P＞0.05）. After treatment， the levels of white blood cells （WBC）， C-reactive protein（ CRP），and erythrocyte sedimentation rate（ ESR） decreased in both groups compared to before treatment，and the Chinese medicine group had lower levels of WBC， CRP， and ESR than the western medicine group （P＜0.05）. After treatment， the scores of primary and secondary symptoms， signs， and tongue manifestation decreased in both groups compared to before treatment， and the Chinese medicine group had lower scores than the western medicine group（ P＜0.05）. The incidence of adverse reactions was 9.80%（ 5/51） in the Chinese medicine group and 19.61%（ 10/ 51） in the western medicine group， with no significant difference between the two groups （P＞0.05）. Conclusion： Yang-supporting cupping therapy combined with western medicine in treating cough of phlegm-damp accumulating in the lung type after MP infection can reduce inflammatory responses， improve immune function， alleviate clinical symptoms，and demonstrates a favorable safety profile.