Abstract： Objective： To observe the clinical efficacy of Chaishao Liujunzi Decoction combined with Pantoprazole in the treatment of patients with gastric ulcer （GU） of liver-qi stagnation and spleen deficiency syndrome. Methods：A total of 89 patients with GU of liver-qi stagnation and spleen deficiency syndrome treated at Community Health Service Center of Buwen Street， Longwen District， Zhangzhou City from January 2024 to August 2025 were enrolled. They were divided into a control group （44 cases） and an observation group（ 45 cases） using a random number table method. Both groups received dietary guidance and smoking/alcohol abstinence. The control group was treated with Pantoprazole Sodium Enteric-Coated Tablets，while the observation group was treated with Chaishao Liujunzi Decoction combined with Pantoprazole Sodium Enteric-Coated Tablets. Both groups were treated continuously for two months. The clinical efficacy， traditional Chinese medicine syndrome scores， Pittsburgh Sleep Quality Index （PSQI） scores， negative psychological state [Hamilton Anxiety Scale （HAMA） and Hamilton Depression Scale （HAMD）] scores，and serum biological indicator [tumor necrosis factor-α （TNF-α），interleukin-6 （IL-6），epidermal growth factor （EGF）] levels were compared between the two groups， and the incidence of adverse reactions was observed. Results： After treatment，the total effective rate in the observation group was 93.33%（ 42/45），higher than that of 77.27%（ 34/44） in the control group （P＜0.05）. After treatment，traditional Chinese medicine syndrome scores in both groups decreased compared with those before treatment （P＜0.05）， and the score in the observation group was lower than that in the control group （P＜0.05）. After treatment，PSQI，HAMA，and HAMD scores in both groups decreased compared with those before treatment （P＜0.05），and the three scores in the observation group were all lower than those in the control group （P＜0.05）. After treatment，serum TNF-α and IL-6 levels in both groups decreased compared with those before treatment （P＜0.05）， while EGF levels increased compared with those before treatment （P＜0.05）； moreover， TNF-α and IL-6 levels in the observation group were lower than those in the control group （P＜0.05），and EGF level in the observation group was higher than that in the control group （P＜0.05）. During treatment， the incidence of adverse reactions was 8.89% （4/45） in the observation group and 13.64% （6/44） in the control group， with no statistically significant difference between the two groups （P＞0.05）. Conclusion： Chaishao Liujunzi Decoction combined with Pantoprazole can improve the clinical symptoms and sleep quality of patients with GU of liver-qi stagnation and spleen deficiency syndrome，alleviate negative psychological states，reduce inflammatory stimulation， effectively repair gastric mucosal damage，and promote the recovery of GU.