Abstract：Objective：To observe the clinical effect of oral Shaofu Zhuyu Granules combined with Chinese medicine iontophoresis and antibiotics in treating acute attack of sequelae of pelvic inflammatory disease （SPID） with cold coagulation and blood stasis complicated with damp-heat stasis obstruction type. Methods：A total of 96 patients suffering from acute attack of SPID with cold coagulation and blood stasis complicated with damp-heat stasis obstruction type admitted to Shaoxing Keqiao Women and Children′s Hospital from January 2021 to December 2024 were enrolled and randomly divided into the observation group and the control group via random number table method，with 48 cases in each group. Both groups received Levofloxacin Hydrochloride Capsules and Metronidazole Tablets；the observation group was additionally given oral Shaofu Zhuyu Granules combined with Chinese medicine iontophoresis. The treatment course lasted 14 days for both groups. Traditional Chinese medicine（TCM） syndrome scores were assessed before and after treatment，and inflammatory indicators [tumor necrosis factor-α （TNF-α） and C-reactive protein （CRP）] as well as hemorheological parameters （plasma viscosity，hematocrit，whole blood high-shear viscosity，whole blood low-shear viscosity） were detected. The clinical effects in the two groups were compared，and the pelvic inflammatory disease recurrence rate within six-month followup among cured patients was analyzed. Results：After 14 days of treatment，the total effective rate in the observation group was significantly higher than that in the control group （P＜0.05）. TCM syndrome scores，levels of TNF-α and CRP， plasma viscosity，hematocrit，whole blood high-shear viscosity，and whole blood low-shear viscosity were all decreased in both groups （P＜0.05），and all seven indicators in the observation group were lower than those in the control group （P＜ 0.05）. During the six-month follow-up period，the recurrence rate of cured patients in the observation group was lower than that in the control group （P＜0.05）. Conclusion：On the basis of antibiotic therapy，additional oral Shaofu Zhuyu Granules combined with Chinese medicine iontophoresis has a definite effect on acute attack of SPID with cold coagulation and blood stasis complicated with damp-heat stasis obstruction type. This combined regimen can effectively relieve clinical symptoms，mitigate inflammatory responses，improve pelvic hemorheological status，and presents unique advantages in lowering the pelvic inflammatory disease recurrence rate and consolidating long-term therapeutic effect.