Abstract： Objective： To observe the efficacy and safety of wrist-ankle acupuncture in the treatment of pharyngeal and laryngeal discomfort after anterior cervical spine surgery （ACSS） under the guidance of the cutaneous region theory. Methods：A total of 72 patients who underwent ACSS with general anesthesia via endotracheal intubation at the Department of Minimally Invasive Spinal Surgery， the General Hospital of Guangdong Provincial Hospital of Chinese Medicine， from March 2023 to February 2024 were enrolled. The patients were randomly divided into the control group and the intervention group using a random number table method，with 36 cases in each group. The control group received routine postoperative care after ACSS， while the intervention group received additional wrist-ankle acupuncture on the basis of the control group′s treatment. Assessments were conducted at 2 hours postoperatively（ before treatment）， 6 hours and 12 hours postoperatively， and on days 1， 2， and 3 after surgery， including evaluation of pharyngeal pain，dysphagia，hoarseness，and choking cough. Results：The Visual Analogue Scale （VAS） scores for pharyngeal pain and choking cough scores in both groups showed a decreasing trend from before treatment to after surgery. Within-group comparisons of VAS scores for pharyngeal pain and choking cough scores at various time points showed statistically significant differences （P＜0.05）. Before treatment， there were no statistically significant differences between the two groups in VAS scores for pharyngeal pain and choking cough scores （P ＞ 0.05）. At 6 hours， 12 hours， and on days 1， 2， and 3 postoperatively， the intervention group showed significantly lower VAS scores for pharyngeal pain and choking cough scores compared to the control group （P＜0.05）. Before treatment， at 6 hours， 12 hours， and on day 1 postoperatively， there were no statistically significant differences in dysphagia between the two groups （P＞0.05）. On days 2 and 3 postoperatively， the differences in dysphagia between the two groups were statistically significant （P＜0.05），with the intervention group showing superior efficacy. Before treatment and at 6 hours postoperatively， there were no statistically significant differences in hoarseness between the two groups （P＞0.05）. At 12 hours and on days 1， 2，and 3 postoperatively，the differences in hoarseness between the two groups were statistically significant （P＜0.05），with the intervention group showing superior efficacy. No adverse events occurred in either group. Conclusion： Wrist-ankle acupuncture based on the cutaneous region theory can effectively alleviate postoperative pharyngeal and laryngeal discomfort symptoms， including pharyngeal pain， dysphagia，hoarseness，and choking cough，after ACSS，thereby promoting rapid recovery of patients.